Virantmycin

Base Information

Chemical Name:Virantmycin
CAS No.:76417-04-4
Molecular Formula:C₁₉H₂₆ClNO₃
Molecular Weight:351.873
Hs Code.:
NSC Number:374127
DSSTox Substance ID:DTXSID40997809
Wikidata:Q77370267
Metabolomics Workbench ID:114216
Mol file:76417-04-4.mol

Synonyms:virantmycin

Suppliers and Price of Virantmycin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
VIRANTMYCIN 95.00%
5MG
$ 504.94

Total 7 raw suppliers

Chemical Property of Virantmycin

Chemical Property:

PSA：58.56000
LogP:4.61990
XLogP3:4.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:351.1601214
Heavy Atom Count:24
Complexity:489

Purity/Quality:

98%,99%, ^*data from raw suppliers

VIRANTMYCIN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=C(C)CCC1(C(CC2=C(N1)C=CC(=C2)C(=O)O)Cl)COC)C

Technology Process of Virantmycin

There total 43 articles about Virantmycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 78983-16-1,104871-13-8,104871-15-0,119239-45-1
(+/-)-virantmycin methyl ester

: 76417-04-4,104871-14-9,104871-16-1,119322-53-1
(+/-)-virantmycin

Guidance literature:: With lithium hydroxide; In water; acetonitrile; at 70 ℃; for 4h;
DOI:10.1016/S0040-4020(01)85583-6

Reference yield: 53.0%

: 201230-82-2
carbon monoxide

: 586390-86-5
(2R,3R)-3-chloro-2-(3,4-dimethylpent-3-enyl)-6-iodo-2-methoxymethyl-1,2,3,4-tetrahydroquinoline

: 76417-04-4
(-)-virantmycin

Guidance literature:: With potassium carbonate; palladium diacetate; In water; N,N-dimethyl-formamide; at 20 ℃; under 760 Torr;
DOI:10.1002/anie.200351069

Reference yield:

: 5072-70-8
1-bromo-2,3-dimethyl-2-butene

: 76417-04-4,104871-14-9,104871-16-1,119322-53-1
(+/-)-virantmycin

Guidance literature:: Multi-step reaction with 14 steps

1: 1.)NaH / 1)THF, 2a) 45 deg C, 1,25 h, 2b) r.t., 20 h

2: 65 percent / propane-1,2-diol, Na / 0.5 h / 83 - 85 °C

3: 68 percent / lithium acetylide-ethylendiamine / tetrahydrofuran; benzene / 1.) 35 deg C, 4 h; 2.) 50 deg C, 1.5 h

4: 94 percent / bis(triphenylphosphine)PdCl₂, CuI / diethylamine / 16 h / Ambient temperature

5: 63 percent / aq. methanesulfonic acid / tetrahydrofuran / 20 h / 40 °C

6: NaBH₄ / methanol / Ambient temperature

7: triphenylphosphine / CCl₄ / 5 h / 54 °C

8: 90 percent / 12 h / Ambient temperature

9: 86 percent / m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂ / 72 h / Ambient temperature

10: 2.) H₂ / 1.) Raney-Ni, 2) Pd-C / 1.) dioxane, 30 min, 2.) dioxane, 1 atm, 21 h

11: 45 percent / tungsten hexachloride-n-butyl lithium / hexane; tetrahydrofuran / 1.) 3 deg C, 30 min; 2.) r.t., 1 h

12: 80 percent / NaOH / methanol / 20 h / Ambient temperature

13: 45 percent / SOCl₂ / CH₂Cl₂ / 5.5 h / 40 °C

14: 73 percent / LiOH*H₂O / acetonitrile; H₂O / 4 h / 70 °C

With lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; propylene glycol; methanesulfonic acid; hydrogen; lithium acetylide-ethylenediamine complex; sodium; sodium hydride; tungsten(VI) chloride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; copper(l) iodide; nickel; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water; diethylamine; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)85583-6