Pentanoic acid, 5-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-5-hydroxy-, 1,1-dimethylethyl ester, (2S)-

Base Information

• Chemical Name: Pentanoic acid, 5-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-5-hydroxy-, 1,1-dimethylethyl ester, (2S)-
• CAS No.: 674790-15-9
• Molecular Formula: C₂₂H₃₅NO₇
• Molecular Weight: 425.522
• Mol file: 674790-15-9.mol

Synonyms:

Chemical Property of Pentanoic acid, 5-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-5-hydroxy-, 1,1-dimethylethyl ester, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentanoic acid, 5-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-5-hydroxy-, 1,1-dimethylethyl ester, (2S)-

There total 1 articles about Pentanoic acid, 5-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-5-hydroxy-, 1,1-dimethylethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl glutamic acid tert-butyl ester (24277-39-2) + dimedone (126-81-8) → tert-butyl (S)-2-tert-butoxycarbonylamino-5-oxo-5-(4,4-dimethyl-2,6-dioxocyclohex-1-yl)pentanoate (674790-15-9)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 24h;

DOI:10.1016/j.tetlet.2003.11.133

Reference yield:

tert-butyl (S)-2-tert-butoxycarbonylamino-5-oxo-5-(4,4-dimethyl-2,6-dioxocyclohex-1-yl)pentanoate (674790-15-9) → 2-amino-4-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-butyric acid (674790-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: DIEA / ethanol

2: TFA

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol;

DOI:10.1016/j.tetlet.2003.11.133

Reference yield:

tert-butyl (S)-2-tert-butoxycarbonylamino-5-oxo-5-(4,4-dimethyl-2,6-dioxocyclohex-1-yl)pentanoate (674790-15-9) → 4-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid

Guidance literature:

Multi-step reaction with 3 steps

1: DIEA / ethanol

2: TFA

3: NaHCO₃(aq) / dioxane

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol;

DOI:10.1016/j.tetlet.2003.11.133

upstream raw materials:

N-tert-butoxycarbonyl glutamic acid tert-butyl ester

dimedone

Downstream raw materials:

4-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

2-amino-4-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-butyric acid