Benzonitrile, 3-[(acetyloxy)methyl]-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy butyl]-

Base Information

Chemical Name:Benzonitrile, 3-[(acetyloxy)methyl]-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy butyl]-
CAS No.:674806-15-6
Molecular Formula:C22H25FN2O3
Molecular Weight:384.451
Hs Code.:

Synonyms:4-(4-dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(acetoxymethyl)benzonitrile;

Suppliers and Price of Benzonitrile, 3-[(acetyloxy)methyl]-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy butyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Benzonitrile, 3-[(acetyloxy)methyl]-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy butyl]-

Chemical Property:

PSA：73.56000
LogP:3.33818

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzonitrile, 3-[(acetyloxy)methyl]-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy butyl]-

There total 3 articles about Benzonitrile, 3-[(acetyloxy)methyl]-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy butyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-24-7
acetic anhydride

: 103146-25-4,219861-18-4,481047-48-7
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

: 674806-15-6
(+/-)-3-(acetoxymethyl)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]benzonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 8h;
DOI:10.1016/j.tetasy.2003.10.022

Reference yield:

: 128173-53-5,912452-31-4
4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile (+)-di-p-toluoyl-D-tartaric acid salt

: 75-36-5
acetyl chloride

: 674806-15-6
(+/-)-3-(acetoxymethyl)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]benzonitrile

Guidance literature:: 4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile (+)-di-p-toluoyl-D-tartaric acid salt; With ammonium hydroxide; In dichloromethane; water; at 10 - 20 ℃; for 0.25h; pH=9 - 11;

acetyl chloride; In dichloromethane; at 20 - 40 ℃; for 2h; Reagent/catalyst;