3-Phenyl-5-[(2-propynyloxy)methyl]-2-oxazolidinone

Base Information

• Chemical Name: 3-Phenyl-5-[(2-propynyloxy)methyl]-2-oxazolidinone
• CAS No.: 23598-54-1
• Molecular Formula: C13H13 N O3
• Molecular Weight: 231.2472
• Hs Code.: 2934999090
• Mol file: 23598-54-1.mol

Synonyms:2-Oxazolidinone,3-phenyl-5-[(2-propynyloxy)methyl]- (8CI,9CI); NSC 154295

Chemical Property of 3-Phenyl-5-[(2-propynyloxy)methyl]-2-oxazolidinone

Chemical Property:

• Vapor Pressure: 3.61E-05mmHg at 25°C
• Boiling Point: 353.3°Cat760mmHg
• Flash Point: 167.5°C
• PSA: 38.77000
• Density: 1.203g/cm³
• LogP: 1.72660

Purity/Quality:

99% ^*data from raw suppliers

3-PHENYL-5-(2-PROPYNYLOXYMETHYL)-2-OXAZOLIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenyl-5-[(2-propynyloxy)methyl]-2-oxazolidinone

There total 8 articles about 3-Phenyl-5-[(2-propynyloxy)methyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

prop-2-ynyloxymethyl-oxirane (18180-30-8) + phenyl isocyanate (103-71-9) → 3-phenyl-5-((prop-2-yn-1-yloxy)methyl)oxazolidin-2-one (23598-54-1)

Guidance literature:

With 3-hydroxy-N-octylpyridinium iodide; In neat (no solvent); at 100 ℃; for 0.333333h; regioselective reaction; Microwave irradiation;

DOI:10.1021/acs.joc.1c01686

Reference yield:

1-chloro-2-phenylcarbamoyloxy-3-prop-2-ynyloxy-propane (33212-02-1) → 3-phenyl-5-((prop-2-yn-1-yloxy)methyl)oxazolidin-2-one (23598-54-1)

Guidance literature:

With potassium hydroxide; In ethanol; at 40 ℃; for 1h;

Reference yield:

phosgene (75-44-5) + 1-anilino-3-prop-2-ynyloxy-propan-2-ol (23452-53-1) → 3-phenyl-5-((prop-2-yn-1-yloxy)methyl)oxazolidin-2-one (23598-54-1)

Guidance literature:

With potassium carbonate; In toluene; at 40 ℃; for 3h;

upstream raw materials:

phosgene

1-anilino-3-prop-2-ynyloxy-propan-2-ol

prop-2-ynyloxymethyl-oxirane

N-carboethoxyaniline