7,8-difluoro-3,4-dihydro-1H-naphthalen-2-one

Base Information

Chemical Name:7,8-difluoro-3,4-dihydro-1H-naphthalen-2-one
CAS No.:675132-40-8
Molecular Formula:C₁₀H₈F₂O
Molecular Weight:182.17
Hs Code.:
European Community (EC) Number:918-254-4
DSSTox Substance ID:DTXSID70400073
Nikkaji Number:J2.536.114H
Wikidata:Q82202900
Mol file:675132-40-8.mol

Synonyms:675132-40-8;7,8-difluoro-3,4-dihydro-1H-naphthalen-2-one;7,8-Difluoro-3,4-dihydronaphthalen-2(1H)-one;2(1H)-Naphthalenone, 7,8-difluoro-3,4-dihydro-;SCHEMBL1142423;DTXSID70400073;BSARDSDOUMFBNL-UHFFFAOYSA-N;BS-51915;Y11802;7,8-Difluoro-3,4-dihydronaphthalene-2(1H)-one;7,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-one

Suppliers and Price of 7,8-difluoro-3,4-dihydro-1H-naphthalen-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Activate Scientific
7,8-Difluoro-3,4-dihydro-1h-naphthalen-2-one 95+%
250 mg
$ 361.00

Total 10 raw suppliers

Chemical Property of 7,8-difluoro-3,4-dihydro-1H-naphthalen-2-one

Chemical Property:

PSA：17.07000
LogP:2.02260
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:182.05432120
Heavy Atom Count:13
Complexity:217

Purity/Quality:

99%, ^*data from raw suppliers

7,8-Difluoro-3,4-dihydro-1h-naphthalen-2-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(CC1=O)C(=C(C=C2)F)F

Technology Process of 7,8-difluoro-3,4-dihydro-1H-naphthalen-2-one

There total 2 articles about 7,8-difluoro-3,4-dihydro-1H-naphthalen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 808144-32-3
(2,3-difluorophenyl)acetyl chloride

: 74-85-1
ethene

: 675132-40-8
7,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-one

Guidance literature:: palladium-carbon;

Reference yield:

: 675132-40-8
7,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-one

Guidance literature:

Reference yield:

: 675132-40-8
7,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-one

: 1096700-64-9
7,8-difluoro-2-(4-propylcyclohexyl)-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / diethyl ether; pentane; paraffin oil (nujol) / 0.5 h / 20 °C

1.2: 2 h / 0 °C

2.1: iron(III)-acetylacetonate; magnesium / 1-methyl-pyrrolidin-2-one; diethyl ether; tetrahydrofuran / -30 °C

3.1: hydrogen / 5% Pd(II)/C(eggshell) / tetrahydrofuran / 19 h / 20 °C / 760.05 Torr

With iron(III)-acetylacetonate; hydrogen; sodium hydride; magnesium; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; paraffin oil (nujol); diethyl ether; pentane;