Chemical Property of nutlin-3B
Chemical Property:
- PKA:14.35±0.20(Predicted)
- PSA：86.96000
- Density:1.36
- LogP:5.47310
- Solubility.:insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
- XLogP3:5.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:6
- Exact Mass:580.1644108
- Heavy Atom Count:40
- Complexity:919
- Purity/Quality:
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99%, *data from raw suppliers
Nutlin3b *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
- Isomeric SMILES:CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
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Description
(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.
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Uses
Nutlin 3b is a small molecule MDM2 antagonist.
