3-Pyridinecarboxylic acid, 6-[[[[1-[2-(methoxymethoxy)-5-methylphenyl]-1H-imidazol-4-yl]methyl][(1- methyl-1H-imidazol-2-yl)methyl]amino]methyl]-

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 6-[[[[1-[2-(methoxymethoxy)-5-methylphenyl]-1H-imidazol-4-yl]methyl][(1- methyl-1H-imidazol-2-yl)methyl]amino]methyl]-
CAS No.:675583-74-1
Molecular Formula:C25H28N6O4
Molecular Weight:476.535
Hs Code.:

3-Pyridinecarboxylic acid,
6-[[[[1-[2-(methoxymethoxy)-5-methylphenyl]-1H-imidazol-4-yl]methyl][(1-
methyl-1H-imidazol-2-yl)methyl]amino]methyl]-

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Chemical Property of 3-Pyridinecarboxylic acid, 6-[[[[1-[2-(methoxymethoxy)-5-methylphenyl]-1H-imidazol-4-yl]methyl][(1- methyl-1H-imidazol-2-yl)methyl]amino]methyl]-

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Technology Process of 3-Pyridinecarboxylic acid, 6-[[[[1-[2-(methoxymethoxy)-5-methylphenyl]-1H-imidazol-4-yl]methyl][(1- methyl-1H-imidazol-2-yl)methyl]amino]methyl]-

There total 9 articles about 3-Pyridinecarboxylic acid, 6-[[[[1-[2-(methoxymethoxy)-5-methylphenyl]-1H-imidazol-4-yl]methyl][(1- methyl-1H-imidazol-2-yl)methyl]amino]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 854779-53-6
6-{[[1-(2-methoxymethoxy-5-methyl-phenyl)-1H-imidazol-4-ylmethyl]-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-nicotinic acid methyl ester

: 675583-74-1
6-{[[1-(2-methoxymethoxy-5-methyl-phenyl)-1H-imidazol-4-ylmethyl]-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-nicotinic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/b311538k

Reference yield:

: 104750-60-9
2-bromo-1-(methoxymethoxy)-4-methylbenzene

: 675583-74-1
6-{[[1-(2-methoxymethoxy-5-methyl-phenyl)-1H-imidazol-4-ylmethyl]-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-nicotinic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / diethyl ether / -70 °C

1.2: 65 percent / B(OMe)3 / diethyl ether

2.1: 75 percent / O₂ / [Cu(OH)TMEDA]2Cl₂ / CH₂Cl₂ / 20 °C

3.1: 93 percent / n-BuN-F / tetrahydrofuran / 20 °C

4.1: 85 percent / MnO₂ / CHCl₃ / Heating

5.1: Et₃N / methanol

6.1: NaBH₄ / methanol

7.1: 61 percent / K₂CO₃ / acetonitrile / 20 °C

8.1: 86 percent / KOH / tetrahydrofuran / 20 °C

With manganese(IV) oxide; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; n-BuN-F; oxygen; potassium carbonate; triethylamine; di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; acetonitrile;
DOI:10.1039/b311538k

Reference yield:

: 478685-71-1
2-(methoxymethoxy)-5-methylbenzeneboronic acid

: 675583-74-1
6-{[[1-(2-methoxymethoxy-5-methyl-phenyl)-1H-imidazol-4-ylmethyl]-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-nicotinic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / O₂ / [Cu(OH)TMEDA]2Cl₂ / CH₂Cl₂ / 20 °C

2: 93 percent / n-BuN-F / tetrahydrofuran / 20 °C

3: 85 percent / MnO₂ / CHCl₃ / Heating

4: Et₃N / methanol

5: NaBH₄ / methanol

6: 61 percent / K₂CO₃ / acetonitrile / 20 °C

7: 86 percent / KOH / tetrahydrofuran / 20 °C

With manganese(IV) oxide; potassium hydroxide; sodium tetrahydroborate; n-BuN-F; oxygen; potassium carbonate; triethylamine; di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1039/b311538k