3-Tosylquinazolin-4(3H)-one

Base Information

Chemical Name:3-Tosylquinazolin-4(3H)-one
CAS No.:5465-78-1
Molecular Formula:C15H12N2O3S
Molecular Weight:300.3324
Hs Code.:
NSC Number:25840
DSSTox Substance ID:DTXSID50969931
Nikkaji Number:J3.286.330B
Wikidata:Q82953004

Synonyms:3-Tosylquinazolin-4(3H)-one;5465-78-1;NSC25840;DTXSID50969931;NSC-25840;3-(4-Methylbenzene-1-sulfonyl)quinazolin-4(3H)-one;3-(4-methylbenzenesulfonyl)-3,4-dihydroquinazolin-4-one

Suppliers and Price of 3-Tosylquinazolin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 3-Tosylquinazolin-4(3H)-one

Chemical Property:

Vapor Pressure:5.28E-10mmHg at 25°C
Boiling Point:496.7°Cat760mmHg
Flash Point:254.2°C
Density:1.36g/cm³
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:300.05686342
Heavy Atom Count:21
Complexity:530

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N2C=NC3=CC=CC=C3C2=O

Technology Process of 3-Tosylquinazolin-4(3H)-one

There total 3 articles about 3-Tosylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 491-36-1
4-Hydroxyquinazoline

: 98-59-9
p-toluenesulfonyl chloride

: 5465-78-1
3-(4-methylbenzenesulfonyl)quinazolin-4(3H)-one

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; regioselective reaction;
DOI:10.1021/jo4010876

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 5465-78-1
3-(4-methylbenzenesulfonyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 4 h / Reflux

2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 2 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo4010876