2-HYDROXY-1-NAPHTHALDEHYDE THIOSEMICARBAZONE

Base Information

• Chemical Name: 2-HYDROXY-1-NAPHTHALDEHYDE THIOSEMICARBAZONE
• CAS No.: 7410-40-4
• Molecular Formula: C12H11N3OS
• Molecular Weight: 245.305
• Hs Code.: 2930909090
• Mol file: 7410-40-4.mol

Synonyms:2-hydroxy-1-naphthalidine-thiosemicarmazone;thiosemicarbazone of 2-hydroxynaphthaldehyde;F3111-2829;2-hydroxy-1-naphthalidene thiosemicarbazone;2-hydroxy-1-naphthaldehydenehydrazinecarbothioamide;2-hydroxynaphthalene-1-carbaldehyde thiosemicarbazone;2-Hydroxy-1-naphthaldehyde thiosemicarbazone;thiosemicarbazone of 2-hydroxy-1-naphthaldehyde;

Chemical Property of 2-HYDROXY-1-NAPHTHALDEHYDE THIOSEMICARBAZONE

Chemical Property:

• Vapor Pressure: 7.38E-09mmHg at 25°C
• Melting Point: 280 °C (decomp)(Solv: acetic acid (64-19-7))
• Boiling Point: 465.9°Cat760mmHg
• PKA: 7.28±0.50(Predicted)
• Flash Point: 235.6°C
• PSA: 102.73000
• Density: 1.446g/cm³
• LogP: 2.80370

Purity/Quality:

99% ^*data from raw suppliers

2-hydroxy-1-naphthaldehydethiosemicarbazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-1-NAPHTHALDEHYDE THIOSEMICARBAZONE

There total 3 articles about 2-HYDROXY-1-NAPHTHALDEHYDE THIOSEMICARBAZONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

thiosemicarbazide (79-19-6) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-hydroxy-1-naphthaldehyde thiosemicarbazone (7410-40-4,1335024-24-2)

Guidance literature:

In ethanol; at 60 - 70 ℃;

Reference yield: 82.0%

thiosemicarbazide (79-19-6) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → o-hydroxynaphthaldehyde thiosemicarbazone (7410-40-4)

Guidance literature:

Reference yield:

thiosemicarbazide hydrochloride (4346-94-5) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-hydroxy-1-naphthaldehyde thiosemicarbazone (7410-40-4,1335024-24-2)

Guidance literature:

With sodium acetate; In water; acetone;

upstream raw materials:

thiosemicarbazide hydrochloride

2-hydroxynaphthalene-1-carbaldehyde

thiosemicarbazide

Downstream raw materials:

[Ni(2-hydroxy-1-naphthaldehyde thiosemicarbazone)(triphenylphosphine)]Cl*H₂O

Refernces

• 1、 Cheng, Jianxin,Huang, Bin,Jiang, Guijjuan,Liao, Xiangwen,Wang, Jing,Wang, Jintao,Wang, Liqiang,Xiong, Yanshi. "The synthesis and evaluation of the antitumor and antibacterial activity of two novel oxovanadium complexes". . p. 1016 - 1021. Retrieved 2021/10/19.
• 2、 Ahmed, Hany E. A.,El-Agrody, Ahmed M.,El-Araby, Moustafa E.,Ihmaid, Saleh,Mohamed, Hany M.,Mora, Ahmed,Omar, Abdelsattar M.,Bajorath, Jürgen. "Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects". . . Retrieved 2020/06/22.