4346-94-5

Basic information

• Product Name: THIOSEMICARBAZIDE HYDROCHLORIDE
• Synonyms: THIOSEMICARBAZIDE HCL;THIOSEMICARBAZIDE HYDROCHLORIDE;THIOSEMICARBAZIDE MONOHYDROCHLORIDE;hydrazinecarbothioamide,monohydrochloride;thio-semicarbazidmonohydrochloride;Nsc191943
• CAS NO: 4346-94-5
• Molecular Formula: CH₆N₃S*Cl
• Molecular Weight: 127.6
• Mol File: 4346-94-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 190-191 °C (decomp)
• Boiling Point: 208.6 °C at 760 mmHg
• Flash Point: 80 °C
• Appearance: /
• Density: 1.376g/cm³
• Water Solubility: Soluble in water
• CAS DataBase Reference: THIOSEMICARBAZIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: THIOSEMICARBAZIDE HYDROCHLORIDE(4346-94-5)
• EPA Substance Registry System: THIOSEMICARBAZIDE HYDROCHLORIDE(4346-94-5)

Safety Data

• RIDADR: UN 2811 6.1/PG III
• RTECS: VT4300000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4346-94-5(Hazardous Substances Data)

Usage

General Description

Thiosemicarbazide hydrochloride is a chemical compound with the formula CH6N4S·HCl. It is a white to off-white crystalline powder that is soluble in water and ethanol. Thiosemicarbazide hydrochloride is primarily used in organic synthesis as a versatile reagent for the preparation of thiosemicarbazones and related compounds. These derivatives have a wide range of applications in medicinal chemistry, pesticide synthesis, and as analytical reagents. Additionally, thiosemicarbazide hydrochloride has been studied for its potential use in corrosion inhibition and as an antimicrobial agent due to its ability to complex with metal ions and exert antibacterial and antifungal activity.

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Relevant articles and documents

Growth and characterization of thiosemicarbazide hydrochloride: A semiorganic NLO material

Thiosemicarbazide hydrochloride (TSCHCL) was synthesized by mixing thiosemicarbazide and hydrochloride in 1:1 molar ratio in double distilled water. Single crystals of TSCHCL were grown by slow evaporation at room temperature and were characterized by single crystal X-ray diffraction study to determine the molecular structure and by FT-IR, 1H and 13C NMR spectral analyses to confirm the synthesized compound. Thermogravimetric and differential thermal analyses reveal the thermal stability of the crystal. The transmission spectrum of TSCHCL showed that the crystal is transparent in the wavelength range 380-1100 nm. High resolution X-ray diffractometry (HRXRD) was employed to evaluate the perfection of the grown crystal. Mechanical properties of the grown crystal were studied using Vickers microhardness test. Second harmonic generation efficiency of the powdered TSCHCL was tested using Nd:YAG laser and is ～1.5 times that of potassium dihydrogen orthophosphate.