4346-94-5

Usage

Uses

Used in Organic Synthesis:
Thiosemicarbazide hydrochloride is used as a reagent for the preparation of thiosemicarbazones and related compounds, which are valuable in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.
Used in Medicinal Chemistry:
In the pharmaceutical industry, thiosemicarbazide hydrochloride is used as a precursor for the synthesis of biologically active compounds with potential applications in the treatment of various diseases, including cancer and infectious diseases.
Used in Pesticide Synthesis:
Thiosemicarbazide hydrochloride is employed as a building block in the synthesis of pesticides, contributing to the development of new and effective crop protection agents.
Used as Analytical Reagents:
In analytical chemistry, thiosemicarbazide hydrochloride serves as a reagent for the detection and quantification of metal ions, owing to its ability to form stable complexes with them.
Used in Corrosion Inhibition:
Thiosemicarbazide hydrochloride has been studied for its potential use in corrosion inhibition, particularly in the protection of metal surfaces from degradation in various industrial applications.
Used as an Antimicrobial Agent:
Due to its complexing ability with metal ions and its antimicrobial properties, thiosemicarbazide hydrochloride is being explored for use as an antimicrobial agent, exhibiting antibacterial and antifungal activity.

Upstream product

• 79-19-6 thiosemicarbazide 

Downstream Products

• 831-71-0 5-nitro-furfural thiosemicarbazone 
• 32003-36-4 4-Oxothiazolidin-2-hydrazon 
• 30131-90-9 5,6-diphenyl-4,5-dihydro-2H-[1,2,4]triazine-3-thione 
• 16566-24-8 1-phenylcarbamimidoyl thiosemicarbazide 
• 344347-12-2 1-(N-acetyl-sulfanilyl)-thiosemicarbazide 
• 74495-43-5 2-amino-5-benzyl-1,3,4-thiadiazine hydrochloride 
• 6139-38-4 methylglyoxal bis(thiosemicarbazone) 
• 114898-82-7 2,5-Diphenyl-3-formylpyrrole thiosemicarbazone 
• 89844-20-2 C₁₁H₁₅N₅O₂S 
• 133436-90-5 Benzoylacetaldehyde thiosemicarbazone 
• 132141-59-4 5-Methyl-3-thioureido-5-(p-tolyl)imidazolidine-2,4-dithione 
• 82577-25-1 1-Phenyl-2-methyl-3-carbethoxy-4-oxoindeno<1,2-b>pyrrole thiosemicarbazone 
• 82577-15-9 1-Benzyl-2-methyl-3-ethoxycarbonyl-4-oxoindeno<1,2-b>pyrrole thiosemicarbazone 
• 133436-94-9 1-Thiocarbamoyl-5-hydroxy-3-methyl-5-phenyl-2-pyrazoline 

Relevant academic research and scientific papers

Growth and characterization of thiosemicarbazide hydrochloride: A semiorganic NLO material

Thiosemicarbazide hydrochloride (TSCHCL) was synthesized by mixing thiosemicarbazide and hydrochloride in 1:1 molar ratio in double distilled water. Single crystals of TSCHCL were grown by slow evaporation at room temperature and were characterized by single crystal X-ray diffraction study to determine the molecular structure and by FT-IR, 1H and 13C NMR spectral analyses to confirm the synthesized compound. Thermogravimetric and differential thermal analyses reveal the thermal stability of the crystal. The transmission spectrum of TSCHCL showed that the crystal is transparent in the wavelength range 380-1100 nm. High resolution X-ray diffractometry (HRXRD) was employed to evaluate the perfection of the grown crystal. Mechanical properties of the grown crystal were studied using Vickers microhardness test. Second harmonic generation efficiency of the powdered TSCHCL was tested using Nd:YAG laser and is ～1.5 times that of potassium dihydrogen orthophosphate.

ISOFLAVONOID ANALOGS AND THEIR METAL CONJUGATES AS ANTI-CANCER AGENTS

A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Cu(II) complex. The isoflavonoid or isoflavonoid mimetic may be non-fragmented steroidal hormone, such as progesterone which is structurally related to the isoflavone genistein, or a small molecule hormone mimetic, such as chromone. An illustrative non-fragmented steroidal embodiment is 17-acetyl-10,13- dimethyl- 1 ,2,6,7, 8,9, 11 , 12, 13 , 14, 15, 16, 17-tetradecahydrocyclopenta[a]phenanthren- 3-tbiosemicarbazone and its Cu(II) complex. Effective chromone analogs include the thiosemicarbazone and hydrazone analogs of 4-oxo-4H-chromene-3-carboxaldehyde and their Cu(IT) complexes.