2-Hydroxy-N-2-pyridinylbenzamide

Base Information

• Chemical Name: 2-Hydroxy-N-2-pyridinylbenzamide
• CAS No.: 13563-04-7
• Molecular Formula: C₁₂H₁₀N₂O₂
• Molecular Weight: 214.224
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00159481
• Nikkaji Number: J1.179.095J
• Wikidata: Q83027814
• ChEMBL ID: CHEMBL458878
• Mol file: 13563-04-7.mol

Synonyms:13563-04-7;2-Hydroxy-N-2-pyridinylbenzamide;2-hydroxy-N-pyridin-2-ylbenzamide;Salicyl-2'-pyridylamide;2-hydroxy-N-(pyridin-2-yl)benzamide;Benzamide, 2-hydroxy-N-2-pyridinyl-;2-hydroxy-N-(2-pyridinyl)benzamide;Salicylamide, N-2-pyridyl-;N-(Pyridin-2-yl)salicylamide;BRN 0172919;2-hydroxy-N-(2-pyridyl)benzamide;5-22-08-00361 (Beilstein Handbook Reference);Benzamide,2-hydroxy-N-2-pyridinyl-;N-2-Pyridylsalicylamide;CBMicro_031021;Oprea1_011338;Oprea1_241125;CHEMBL458878;SCHEMBL17675194;CCG-489;DTXSID00159481;HMS1676H16;N-(2-Pyridyl)-2-hydroxybenzamide;MFCD00124203;STK164575;AKOS000207040;LS-09017;LS-27019;BIM-0030915.P001;CS-0116853;AE-641/02605026;Z56871634;5559-94-4

Chemical Property of 2-Hydroxy-N-2-pyridinylbenzamide

Chemical Property:

• Vapor Pressure: 0.000246mmHg at 25°C
• Melting Point: 203 °C
• Boiling Point: 314.8°Cat760mmHg
• PKA: 8.49±0.30(Predicted)
• Flash Point: 144.2°C
• PSA: 62.22000
• Density: 1.339g/cm³
• LogP: 2.11250
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 214.074227566
• Heavy Atom Count: 16
• Complexity: 245

Purity/Quality:

98% ^*data from raw suppliers

2-Hydroxy-N-pyridin-2-ylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NC2=CC=CC=N2)O

Technology Process of 2-Hydroxy-N-2-pyridinylbenzamide

There total 10 articles about 2-Hydroxy-N-2-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-aminopyridine (504-29-0) + phenyl Salicylate (118-55-8) → N-(2'-pyridyl)-2-hydroxybenzamide (13563-04-7)

Guidance literature:

at 190 - 210 ℃; for 1.5h;

DOI:10.1016/j.farmac.2004.02.003

Reference yield: 45.0%

2-aminopyridine (504-29-0) + 2-Hydroxybenzoylhydrazine (936-02-7) → N-(2'-pyridyl)-2-hydroxybenzamide (13563-04-7)

Guidance literature:

With mercury(II) oxide; In benzene; for 0.5h;

Reference yield:

pyridine N-oxide (694-59-7) → N-(2'-pyridyl)-2-hydroxybenzamide (13563-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / CH₂Cl₂ / 5 h / Heating

2: 0.20 g / 10percent HCl / Ambient temperature

With hydrogenchloride; In dichloromethane;

upstream raw materials:

2-aminopyridine

phenyl Salicylate

O-acetylsalicyloyl chloride

2-Hydroxybenzoylhydrazine

Downstream raw materials:

2-<(o-hydroxybenzyl)amino>pyridine

Refernces

• 1、 Waisser, Karel,Drazkova, Katerina,Kunes, Jiri,Klimesova, Vera,Kaustova, Jarmila. "Antimycobacterial N-pyridinylsalicylamides, isosters of salicylamides". . p. 615 - 625. Retrieved 2007/10/03.
• 2、 Daidone,Maggio,Schillaci. "Salicylanilide and its heterocyclic analogues. A comparative study of their antimicrobial activity". . p. 441 - 442. Retrieved 2007/10/02.