2-Hydroxybenzohydrazide

Base Information

• Chemical Name: 2-Hydroxybenzohydrazide
• CAS No.: 936-02-7
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 29280000
• European Community (EC) Number: 213-311-3,923-931-2
• NSC Number: 652
• UNII: R5T5F3Q8HR
• DSSTox Substance ID: DTXSID0061321
• Nikkaji Number: J30.699A
• Wikidata: Q72506931
• ChEMBL ID: CHEMBL170058
• Mol file: 936-02-7.mol

Synonyms:salicyl hydrazide

Chemical Property of 2-Hydroxybenzohydrazide

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Melting Point: 147-150 °C(lit.)
• Refractive Index: 1.622
• Boiling Point: 274.61°C (rough estimate)
• PKA: 8.57±0.30(Predicted)
• PSA: 75.35000
• Density: 1.318 g/cm³
• LogP: 1.08690
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: soluble in Ethanol,Methanol
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 152.058577502
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NN)O

Technology Process of 2-Hydroxybenzohydrazide

There total 26 articles about 2-Hydroxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl salicylate (119-36-8,8024-54-2) → 2-Hydroxybenzoylhydrazine (936-02-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.0166667h; microwave irradiation;

DOI:10.1080/07328300802030795

Reference yield: 89.0%

salicylic acid (69-72-7,25496-36-0,8052-31-1) → 2-Hydroxybenzoylhydrazine (936-02-7)

Guidance literature:

With hydrazine hydrate; for 0.0388889h; Microwave irradiation;

Reference yield: 74.4%

n-butyl salicylate (2052-14-4) → 2-Hydroxybenzoylhydrazine (936-02-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

DOI:10.1134/S1070363215030330

upstream raw materials:

2-hydroxy-benzoic acid ethyl ester

methyl salicylate

N'-benzylidene-2-hydroxybenzohydrazide

2'-(4-dimethylaminobenzylidene)-2-hydroxybenzoylhydrazide

Downstream raw materials:

N-benzenesulfonyl-N'-salicyloyl-hydrazine

2-hydroxy-N’-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]benzhydrazide

2-hydroxy-benzoic acid furfurylidenehydrazide

3-(2-Hydroxyphenyl)-4,5-pentamethylen-1,2,4-triazol

Refernces

• 1、 Kumar,Chanu,Borthakur,Lal. "Characterization of heterobimetallic and mixed-valence complexes of molybdenum(V) derived from bis(2-hydroxy-1-naphthaldehyde) malonoyldihydrazone". . p. 866 - 875. Retrieved 2012.
• 2、 Adly, Omima M.I.,Shebl, Magdy,El-Shafiy, Hoda F.,Khalil, Saied M.E.,Taha,Mahdi, Mohammed A.N.. "Synthesis, spectroscopic characterization, antimicrobial and antitumor studies of mono-, bi- and tri-nuclear metal complexes of a new Schiff base ligand derived from o-acetoacetylphenol". . p. 507 - 522. Retrieved 2017.
• 3、 Uddin, Mohammad Nasir,Khandaker, Sonia,Moniruzzaman,Amin, Md. Shaharier,Shumi, Wahhida,Rahman, Md. Atiar,Rahman, Sheikh Mahbubur. "Synthesis, characterization, molecular modeling, antioxidant and microbial properties of some Titanium(IV) complexes of schiff bases". . p. 79 - 90. Retrieved 2018.
• 4、 Gul, Zarif,Hayat, Shawkat,Hussain, Javid,Khan, Fahad,Khan, Misbah Ullah,Rahim, Fazal,Sobia,Taha, Muhammad,Uddin, Imad,Ullah, Hayat,Ullah, Munzer,Ullah, Shaheed,Zada, Hussan. "In vitro α-glucosidase and α-amylase inhibitory potential and molecular docking studies of benzohydrazide based imines and thiazolidine-4-one derivatives". . . Retrieved 2021/12/10.
• 5、 -. "POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER". Paragraph 00173; 00176-00177. . Retrieved 2021/07/10.