Technology Process of 5,7-Quinolinedicarboxylic acid,
3-[(4-fluorophenyl)methyl]-8-(phenylmethoxy)-, 7-methyl ester
There total 1 articles about 5,7-Quinolinedicarboxylic acid,
3-[(4-fluorophenyl)methyl]-8-(phenylmethoxy)-, 7-methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyl 8-benzyloxy-5-bromo-3-(4-fluorobenzyl)quinoline-7-carboxylate;
With
1,3-bis-(diphenylphosphino)propane; water; triethylamine;
palladium diacetate;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.5h;
carbon monoxide;
In
dimethyl sulfoxide;
at 20 - 70 ℃;
for 21h;
under 760.051 Torr;
- Guidance literature:
-
C26H20FNO5;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 50 ℃;
for 0.25h;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 20 ℃;
for 0.75h;
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
- Guidance literature:
-
C26H20FNO5; (S)-2-amino-N,N-dimethylpropanamide hydrochloride;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 6h;
With
hydrogenchloride;
In
DMF (N,N-dimethyl-formamide); water;
