Suriclone

Base Information

Chemical Name:Suriclone
CAS No.:53813-83-5
Molecular Formula:C20H20 Cl N5 O3 S2
Molecular Weight:477.995
Hs Code.:
European Community (EC) Number:258-794-1
UNII:LNC9G689VR
DSSTox Substance ID:DTXSID20866362
Nikkaji Number:J10.865K
Wikipedia:Suriclone
Wikidata:Q7646277
NCI Thesaurus Code:C96876
Metabolomics Workbench ID:155794
ChEMBL ID:CHEMBL2105561
Mol file:53813-83-5.mol

Synonyms:(8-(7-chloro(1,8)naphthyridin-2-yl)-7-oxo-2,5-dithia-8-azabicyclo(4.3.0)non-10-en-9-yl) 4-methylpiperazine-1-carboxylate;6-(7-chloro-1,8-naphthyridin-2-yl)-2,3,6,7-tetrahydro-7-oxo-5H-(1,4)dithiino(2,3-c)pyrrol-5-yl-4-methylpiperazine-1-carboxylate;RP 31264;RP-3124;RP-31264;suriclone

Suppliers and Price of Suriclone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
SURICLONE 95.00%
5MG
$ 498.67

Total 36 raw suppliers

Chemical Property of Suriclone

Chemical Property:

Vapor Pressure:7.12E-17mmHg at 25°C
Melting Point:280°
Boiling Point:651.9°Cat760mmHg
PKA:6.81±0.10(Predicted)
Flash Point:348°C
PSA：129.47000
Density:1.59g/cm³
LogP:2.97230
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:477.0696096
Heavy Atom Count:31
Complexity:763

Purity/Quality:

99% ^*data from raw suppliers

SURICLONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C(=O)OC2C3=C(C(=O)N2C4=NC5=C(C=C4)C=CC(=N5)Cl)SCCS3
Description Suriclone is one of the most potent of all agents known to act at the benzodiazepine receptor. Its anxiolytic effects have been clearly demonstrated in rodents (Doble et al. 1992). It has also been demonstrated to be efficacious in the treatment of generalized anxiety disorder in humans (Ansseau et al. 1991). Animal work has shown it to have fewer side effects and less potential for interacting with alcohol than do benzodiazepines. These would represent significant advantages if they were also seen in humans. Repeated doses have failed to show tolerance and do not produce the change in “set point” of the GABAA receptor seen with the benzodiazepines. The reason for this is unclear but may be linked to a difference in the interaction of the cyclopyrrolones with the receptor compared with that of the benzodiazepines.

Technology Process of Suriclone

There total 1 articles about Suriclone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: