4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol

Base Information

Chemical Name:4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol
CAS No.:5876-17-5
Molecular Formula:C13H11NO4
Molecular Weight:245.235
Hs Code.:
ChEMBL ID:CHEMBL400257,CHEMBL455007
DSSTox Substance ID:DTXSID30974280
Metabolomics Workbench ID:68287,135388
Nikkaji Number:J13.625E
Pharos Ligand ID:B3TDRWNPNPPM
Wikidata:Q27106828,Q104696536
Mol file:5876-17-5.mol

Synonyms:7-hydroxy-8-methoxydictamine;Heliparvifoline;Haplopine;

Suppliers and Price of 4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Haplopine 95+%
5mg
$ 802.00

Arctom
Haplopine ≥98%
5mg
$ 413.00

American Custom Chemicals Corporation
4,8-DIMETHOXY-FURO[2,3-B]QUINOLIN-7-OL 95.00%
5MG
$ 501.48

Total 13 raw suppliers

Chemical Property of 4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol

Chemical Property:

Vapor Pressure:5.74E-12mmHg at 25°C
Melting Point:202-204 °C
Boiling Point:545.8°Cat760mmHg
PKA:5.60±0.30(Predicted)
Flash Point:283.9°C
PSA：64.72000
Density:1.37g/cm³
LogP:2.70380
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:245.06880783
Heavy Atom Count:18
Complexity:301

Purity/Quality:

98%Min ^*data from raw suppliers

Haplopine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C2C=COC2=NC3=C1C=CC(=C3OC)O
Description A further Haplophyllum alkaloid, this base occurs in H. perforatum (MB) Kar. et Kir. and in H. robustum Bge. It crystallizes as small colourless needles from MeOH and has been characterized as the crystalline hydrochloride, m.p. 168- 9°C. The base may be isomerized to isohaplopine, which forms colourless rods from MeOH with m.p. 170-2°C.

Technology Process of 4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol

There total 17 articles about 4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 119188-51-1
4-methoxyfuro[2,3-b]quinoline-7,8-diol

: 5876-17-5,1363-10-6
4,8-Dimethoxy-furo[2,3-b]quinolin-7-ol

Guidance literature:: DOI:10.1039/b506944k

Reference yield:

: 83-95-4
skimmianine

: 5876-17-5,1363-10-6
4,8-Dimethoxy-furo[2,3-b]quinolin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / BBr₃

With boron tribromide;
DOI:10.1039/b506944k

Reference yield:

: 865878-14-4
(7S,8R)-4-methoxy-7,8-dihydrofuro[2,3-b]quinoline-7,8-diol

: 5876-17-5,1363-10-6
4,8-Dimethoxy-furo[2,3-b]quinolin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: E_. coli nar B naphthalene cis-diol dehydrogenase

With E_. coli nar B naphthalene cis-diol dehydrogenase;
DOI:10.1039/b506944k