(1-Tosyl-1H-Indol-3-Yl)Methanol

Base Information

• Chemical Name: (1-Tosyl-1H-Indol-3-Yl)Methanol
• CAS No.: 67593-11-7
• Molecular Formula: C16H15NO3S
• Molecular Weight: 301.366
• Mol file: 67593-11-7.mol

Synonyms:1-[(4-methylphenyl)sulphonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine;3-hydroxymethyl-1-tosyl-1H-indole;1-[(4-Methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine;1-(p-toluenesulfonyl)-3-hydroxymethylindole;1-[(4-methylphenyl)sulfonyl]indol-3-ylmethanol;(1-tosyl-1H-indol-3-yl)carbinol;1-Tosyl-1H-Pyrrolo[2,3-B]pyridine-4-boronic acid pinacol ester;[1-tosyl-1Hindol-3-yl]methanol;1-tosylindole-3-methanol;3-hydroxymethyl-1-tosylindole;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(toluene-4-suIfonyl)-1H-pyrrolo[2,3-b]pyridine;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine;

Chemical Property of (1-Tosyl-1H-Indol-3-Yl)Methanol

Chemical Property:

• PSA: 78.54000
• LogP: 4.02190

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1-Tosyl-1H-Indol-3-Yl)Methanol

There total 15 articles about (1-Tosyl-1H-Indol-3-Yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(4-tolylsulfonyl)indole-3-carboxaldehyde (50562-79-3) → 1-[(4-methylphenyl)sulfonyl]indol-3-ylmethanol (67593-11-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.5h;

DOI:10.1002/chem.200204620

Reference yield: 92.6%

1-tosyl-1H-indole-3-carbaldehyde → 1-[(4-methylphenyl)sulfonyl]indol-3-ylmethanol (67593-11-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 5 ℃; for 1h;

Reference yield: 83.0%

ethyl 1-tosyl-1H-indole-3-carboxylate → 1-[(4-methylphenyl)sulfonyl]indol-3-ylmethanol (67593-11-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201406278

upstream raw materials:

1-(4-tolylsulfonyl)indole-3-carboxaldehyde

Indole-3-carboxaldehyde

p-toluenesulfonyl chloride

methylmagnesium chloride

Downstream raw materials:

3-(bromomethyl)-1-[(4-methylphenyl)sulfonyl]-1H-indole

1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbonitrile

(toluene-4-sulfonyl)-acetic acid 1-(toluene-4-sulfonyl)-1H-indol-3-ylmethyl ester

1-p-toluenesulfonyl-1H-indole-3-carboxamide