Synonyms:Methylmagnesiumchloride (6CI);Chloromethylmagnesium;
99% *data from raw suppliers
Methylmagnesium chloride, 3M in THF *data from reagent suppliers
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There total 4 articles about Methylmagnesium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The research investigates the nickel-mediated cross-coupling of unactivated neopentyl iodides with organozinc reagents, catalyzed by dichloro(1,1'-bis(diphenylphosphino)ferrocene)nickel(II) ((dppf)NiCl2). The study explores the formation of zinc nucleophiles by treating ZnCl2-dioxane with Grignard reagents in an ethereal solvent, finding that the cross-coupling works optimally for diorganozincs formed from aryl chlorides or CH3MgCl, while aryl bromides can cause reduction and/or reductive dimerization of the electrophile. The research highlights that the use of organozincs overcomes many side reactions observed with the (dppf)-NiCl2-mediated cross-coupling of Grignard reagents. The study also examines the effects of varying the halide in the Grignard reagent and the influence of different solvents and catalysts on the reaction outcomes. Key chemicals involved in the research include neopentyl iodides, various Grignard reagents (such as CH3MgCl, PhMgCl, etc.), ZnCl2-dioxane, and (dppf)NiCl2, with the findings suggesting that organomagnesium chlorides are the reagents of choice for achieving higher yields and cleaner reaction mixtures.
The study investigates the relative reactivities of methylmagnesium chloride and dimethylmagnesium, focusing on their interactions with various carbonyl compounds in different solvents. Methylmagnesium chloride and dimethylmagnesium are the primary reagents used, with dioxane and isoamyl ether serving as solvents. The researchers found that dimethylmagnesium exhibits a preference for reacting with hydroxyl groups over carbonyl groups, forming ene-diol magnesium salts and resulting in less reactivity toward carbonyl functions compared to methylmagnesium chloride. This was demonstrated through reactions with benzoin, acetophenone, desoxybenzoin, and diphenylacetophenone, where dimethylmagnesium showed lower yields and incomplete reactions. The study also highlights the influence of solvents on reaction outcomes and suggests that the presence of dioxane does not alter the reaction course significantly.
The study investigates the reactions of (1-chlorovinyl)diphenylphosphine oxide with various organometallic reagents, including Grignard reagents and organocuprates, to explore the reactivity patterns and potential synthetic applications. The (1-chlorovinyl)diphenylphosphine oxide acts as a substrate, reacting with different organometallic compounds to form phosphine oxides. With Grignard reagents such as methylmagnesium chloride and aryl Grignard reagents, the reactions yield phosphine oxides with good isolated yields, indicating the chlorovinyl group's effectiveness as a leaving group. When reacting with organocuprates, a more complex product distribution is observed, with the formation of phosphine oxides and vinylphosphine oxides, depending on the specific organocuprate used. The study highlights the potential for synthesizing different types of phosphine oxides from a common precursor through reactions with various organometallic reagents, demonstrating the versatility of the chlorovinyl group in heteroatom chemistry.
The study investigates a novel method for synthesizing gem-di?uoroalkenes through a rhodium-catalyzed addition reaction involving arylboronic esters and methylmagnesium chloride. The key chemicals in this study include β-(tri?uoromethyl)styrenes, which act as the substrates, arylboronic esters that serve as the arylating agents, and methylmagnesium chloride that enhances the β-?uoride elimination step. The rhodium(I) catalyst, specifically [Rh(OH)(cod)]2 or [RhCl(cod)]2, facilitates the reaction by generating an organorhodium(I) intermediate. This intermediate undergoes β-?uoride elimination to produce the desired gem-di?uoroalkenes. The study optimizes reaction conditions, demonstrating that using phenylboronic esters instead of phenylboronic acid increases the yield of the target product. The scope of the reaction is explored with various arylboronic esters and substrates, revealing that electron-donating groups enhance reactivity while electron-withdrawing groups and alkyl substitutions reduce it. The optimized conditions yield gem-di?uoroalkenes in good yields, showcasing a rare example of β-?uoride elimination in organorhodium(I) complexes.
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