1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-ethyl-3,4-dihydro-, phenylmethyl ester

Base Information

Chemical Name:1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-ethyl-3,4-dihydro-, phenylmethyl ester
CAS No.:676136-43-9
Molecular Formula:C31H35F2N3O4
Molecular Weight:551.633
Hs Code.:

1(2H)-Quinolinecarboxylic acid,
4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino
]-6-ethyl-3,4-dihydro-, phenylmethyl ester

Synonyms:

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Chemical Property of 1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-ethyl-3,4-dihydro-, phenylmethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-ethyl-3,4-dihydro-, phenylmethyl ester

There total 2 articles about 1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-ethyl-3,4-dihydro-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676136-42-8
benzyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-ethyl-3,4-dihydroquinoline-1(2H)-carboxylate

: 128459-09-6
N-acetyl-N-methoxyacetamide

: 676136-43-9
benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-ethyl-3,4-dihydroquinoline-1(2H)-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: benzyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-ethyl-3,4-dihydroquinoline-1(2H)-carboxylate

: 128459-09-6
N-acetyl-N-methoxyacetamide

: 676136-43-9
benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-ethyl-3,4-dihydroquinoline-1(2H)-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 676136-43-9
benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-ethyl-3,4-dihydroquinoline-1(2H)-carboxylate

: 676136-35-9
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(6-ethyl-1,2,3,4-tetrahydroquinolin-4-yl)amino]-2-hydroxypropyl}acetamide

Guidance literature:: benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-ethyl-3,4-dihydroquinoline-1(2H)-carboxylate; With hydrogen; acetic acid; palladium 10% on activated carbon; In ethanol; for 1.25h; under 2689.24 Torr;

With sodium hydroxide; In water; ethyl acetate;