Technology Process of 2-Oxazolidinone,
3-[(3R,5S)-5-[(4-methoxyphenyl)methoxy]-3,6,6-trimethyl-1-oxoheptyl]-4
-phenyl-, (4S)-
There total 3 articles about 2-Oxazolidinone,
3-[(3R,5S)-5-[(4-methoxyphenyl)methoxy]-3,6,6-trimethyl-1-oxoheptyl]-4
-phenyl-, (4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methylmagnesium bromide;
With
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran; diethyl ether;
at -40 ℃;
for 1h;
(4S)-3-[(5S)-5-(4-methoxybenzyloxy)-6,6-dimethylhept-2-enoyl]-4-phenyloxazolidin-2-one;
In
tetrahydrofuran; diethyl ether;
at -78 - 20 ℃;
DOI:10.1016/j.tetasy.2003.11.026
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: KHMDS; HMPA / tetrahydrofuran; toluene / -70 - 20 °C
1.2: 69 percent / tetrahydrofuran; toluene / 16 h / -70 °C
2.1: copper(I) bromide-dimethyl sulfide complex / tetrahydrofuran; various solvent(s); diethyl ether / 1 h / -40 °C
2.2: 92 percent / tetrahydrofuran; various solvent(s); diethyl ether / -78 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex; potassium hexamethylsilazane;
In
tetrahydrofuran; diethyl ether; toluene;
1.2: Wadsworth-Emmons condensation;
DOI:10.1016/j.tetasy.2003.11.026
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1.17 g / sodium periodate on silica gel / CH2Cl2 / 0.5 h / 20 °C
2.1: KHMDS; HMPA / tetrahydrofuran; toluene / -70 - 20 °C
2.2: 69 percent / tetrahydrofuran; toluene / 16 h / -70 °C
3.1: copper(I) bromide-dimethyl sulfide complex / tetrahydrofuran; various solvent(s); diethyl ether / 1 h / -40 °C
3.2: 92 percent / tetrahydrofuran; various solvent(s); diethyl ether / -78 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium periodate; copper(I) bromide dimethylsulfide complex; potassium hexamethylsilazane;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
2.2: Wadsworth-Emmons condensation;
DOI:10.1016/j.tetasy.2003.11.026
