L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-seryl-S-[[2-carboxy-6-[[(1,1-dimethyl ethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphenyl]methyl]-, 21-methyl ester

Base Information

Chemical Name:L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-seryl-S-[[2-carboxy-6-[[(1,1-dimethyl ethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphenyl]methyl]-, 21-methyl ester
CAS No.:676347-42-5
Molecular Formula:C28H46N2O10SSi
Molecular Weight:630.832
Hs Code.:

L-Cysteine,
N-[(1,1-dimethylethoxy)carbonyl]-L-seryl-S-[[2-carboxy-6-[[(1,1-dimethyl
ethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphenyl]methyl]-, 21-methyl
ester

Synonyms:

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Chemical Property of L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-seryl-S-[[2-carboxy-6-[[(1,1-dimethyl ethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphenyl]methyl]-, 21-methyl ester

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Technology Process of L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-seryl-S-[[2-carboxy-6-[[(1,1-dimethyl ethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphenyl]methyl]-, 21-methyl ester

There total 4 articles about L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-seryl-S-[[2-carboxy-6-[[(1,1-dimethyl ethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphenyl]methyl]-, 21-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676347-08-3
methyl N-[N-tert-butoxycarbonyl-L-seryl]-S-[6-(tert-butyl)dimethylsilyloxy-4-methoxy-3-methyl-2-(4-nitrobenzyloxycarbonyl)benzyl]-L-cysteinate

: 676347-42-5
2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propionylamino)-2-methoxycarbonyl-ethylsulfanylmethyl]-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-6-methyl-benzoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 18h;
DOI:10.1021/jm0310232

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 676347-42-5
2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propionylamino)-2-methoxycarbonyl-ethylsulfanylmethyl]-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-6-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / Et₃N / dimethylformamide / 0 °C

2.1: NBS / CCl₄ / 0.67 h / Heating; irradiation

2.2: 27 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

With N-Bromosuccinimide; hydrogen; triethylamine; palladium on activated charcoal; In tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232

Reference yield:

: 676346-99-9
4-nitrobenzyl 3-hydroxy-5-methoxy-2,6-dimethylbenzoate

: 676347-42-5
2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propionylamino)-2-methoxycarbonyl-ethylsulfanylmethyl]-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-6-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / Et₃N / dimethylformamide / 0 °C

2.1: NBS / CCl₄ / 0.67 h / Heating; irradiation

2.2: 27 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

With N-Bromosuccinimide; hydrogen; triethylamine; palladium on activated charcoal; In tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232