formyl-cyclo(cysteinyl-leucyl-phenylalanyl-cysteinyl) methyl ester

Base Information

Chemical Name:formyl-cyclo(cysteinyl-leucyl-phenylalanyl-cysteinyl) methyl ester
CAS No.:153824-53-4
Molecular Formula:C₂₃H₃₂N₄O₆S₂
Molecular Weight:524.662
Hs Code.:
Mol file:153824-53-4.mol

Synonyms:1,2-Dithia-5,8,11-triazacyclotetradecane,cyclic peptide deriv.

Suppliers and Price of formyl-cyclo(cysteinyl-leucyl-phenylalanyl-cysteinyl) methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of formyl-cyclo(cysteinyl-leucyl-phenylalanyl-cysteinyl) methyl ester

Chemical Property:

Vapor Pressure:1.13E-30mmHg at 25°C
Boiling Point:869.5°Cat760mmHg
Flash Point:479.6°C
Density:1.243g/cm³

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of formyl-cyclo(cysteinyl-leucyl-phenylalanyl-cysteinyl) methyl ester

There total 8 articles about formyl-cyclo(cysteinyl-leucyl-phenylalanyl-cysteinyl) methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 153824-53-4
For-cyclo-OMe

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 95percent isobutyl chloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -15 deg C, 10 min, 2.) CH₂Cl₂, DMF, -15 deg C, 15 min; r.t., overnight

2: HCl / tetrahydrofuran

3: 1.) 95percent isobutyl chloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -15 deg C, 10 min, 2.) CH₂Cl₂, DMF, -15 deg C, 15 min; r.t., overnight

4: 94 percent / I₂ / methanol

5: 2.) 97percent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / 1.) r.t., overnight, 2.) DMF, r.t., 17 h

With 4-methyl-morpholine; hydrogenchloride; iodine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; isobutyl chloroformate; In tetrahydrofuran; methanol;
DOI:10.1002/ardp.19933261208

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 153824-53-4
For-cyclo-OMe

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 95percent isobutyl chloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -15 deg C, 10 min, 2.) CH₂Cl₂, DMF, -15 deg C, 15 min; r.t., overnight

2: HCl / tetrahydrofuran

3: 1.) 95percent isobutyl chloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -15 deg C, 10 min, 2.) CH₂Cl₂, DMF, -15 deg C, 15 min; r.t., overnight

4: HCl / tetrahydrofuran

5: 1.) 95percent isobutyl chloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -15 deg C, 10 min, 2.) CH₂Cl₂, DMF, -15 deg C, 15 min; r.t., overnight

6: 94 percent / I₂ / methanol

7: 2.) 97percent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / 1.) r.t., overnight, 2.) DMF, r.t., 17 h

With 4-methyl-morpholine; hydrogenchloride; iodine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; isobutyl chloroformate; In tetrahydrofuran; methanol;
DOI:10.1002/ardp.19933261208

Reference yield:

: 153824-49-8
Boc-Phe-Cys(Acm)-OMe

: 153824-53-4
For-cyclo-OMe

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / tetrahydrofuran

2: 1.) 95percent isobutyl chloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -15 deg C, 10 min, 2.) CH₂Cl₂, DMF, -15 deg C, 15 min; r.t., overnight

3: HCl / tetrahydrofuran

4: 1.) 95percent isobutyl chloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -15 deg C, 10 min, 2.) CH₂Cl₂, DMF, -15 deg C, 15 min; r.t., overnight

5: 94 percent / I₂ / methanol

6: 2.) 97percent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / 1.) r.t., overnight, 2.) DMF, r.t., 17 h

With 4-methyl-morpholine; hydrogenchloride; iodine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; isobutyl chloroformate; In tetrahydrofuran; methanol;
DOI:10.1002/ardp.19933261208