2-Methyl-4-phenyl-3,4-dihydro-1H-2-benzazepine-1,5(2H)-dione

Base Information

• Chemical Name: 2-Methyl-4-phenyl-3,4-dihydro-1H-2-benzazepine-1,5(2H)-dione
• CAS No.: 67643-54-3
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.312
• DSSTox Substance ID: DTXSID00497512

Synonyms:67643-54-3;DTXSID00497512;2-Methyl-4-phenyl-3,4-dihydro-1H-2-benzazepine-1,5(2H)-dione

Chemical Property of 2-Methyl-4-phenyl-3,4-dihydro-1H-2-benzazepine-1,5(2H)-dione

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 265.110278721
• Heavy Atom Count: 20
• Complexity: 387

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CC(C(=O)C2=CC=CC=C2C1=O)C3=CC=CC=C3

Technology Process of 2-Methyl-4-phenyl-3,4-dihydro-1H-2-benzazepine-1,5(2H)-dione

There total 4 articles about 2-Methyl-4-phenyl-3,4-dihydro-1H-2-benzazepine-1,5(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-methylphthalimide (550-44-7) + isopropyl alcohol (67-63-0,8013-70-5) → 6,7-dihydro-1-methyl-6-phenyl-3,4-benzazepine-2,5-dione (67643-54-3) + (R,R and S,S)-3-hydroxy-3-(2-isopropoxy-1-phenylethyl)-2-methylisoindolin-1-one (95362-80-4) + (R,S and S,R)-3-hydroxy-3-(2-isopropoxy-1-phenylethyl)-2-methylisoindolin-1-one (95362-76-8)

Guidance literature:

for 3h; Irradiation;

DOI:10.1021/jo00209a015

Reference yield: 28.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-methylphthalimide (550-44-7) → 6,7-dihydro-1-methyl-6-phenyl-3,4-benzazepine-2,5-dione (67643-54-3) + (R,R and S,S)-3-hydroxy-3-(2-tert-butoxy-1-phenylethyl)-2-methylisoindolin-1-one (95362-81-5) + (R,S and S,R)-3-hydroxy-3-(2-tert-butoxy-1-phenylethyl)-2-methylisoindolin-1-one (95362-77-9)

Guidance literature:

In tert-butyl alcohol; for 3h; Irradiation;

DOI:10.1021/jo00209a015

Reference yield: 28.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-methylphthalimide (550-44-7) + tert-butyl alcohol (75-65-0) → 6,7-dihydro-1-methyl-6-phenyl-3,4-benzazepine-2,5-dione (67643-54-3) + (R,R and S,S)-3-hydroxy-3-(2-tert-butoxy-1-phenylethyl)-2-methylisoindolin-1-one (95362-81-5) + (R,S and S,R)-3-hydroxy-3-(2-tert-butoxy-1-phenylethyl)-2-methylisoindolin-1-one (95362-77-9)

Guidance literature:

for 3h; Irradiation;

DOI:10.1021/jo00209a015

upstream raw materials:

styrene

N-methylphthalimide

isopropyl alcohol

tert-butyl alcohol

Downstream raw materials:

6,7-dihydro-5-hydroxy-1-methyl-6-phenyl-3,4-benzazepin-2(5H)-one

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