2- iodine -6- fluoro formamide

Base Information

• Chemical Name: 2- iodine -6- fluoro formamide
• CAS No.: 676445-27-5
• Molecular Formula: C7H5FINO
• Molecular Weight: 265.026
• Hs Code.: 2924299090
• Mol file: 676445-27-5.mol

Synonyms:2-fluoro-6-iodobenzamide;

Chemical Property of 2- iodine -6- fluoro formamide

Chemical Property:

• PSA: 43.09000
• LogP: 2.22950

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-6-iodobenzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2- iodine -6- fluoro formamide

There total 2 articles about 2- iodine -6- fluoro formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-6-iodobenzoic acid (111771-08-5) → 6-fluoro-2-iodobenzamide (676445-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1.25 h / 20 °C

2: ammonia (gas) / CH₂Cl₂

With oxalyl dichloride; ammonia; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm061094b

Reference yield:

2-fluoro-6-iodobenzoyl chloride (111771-12-1) → 6-fluoro-2-iodobenzamide (676445-27-5)

Guidance literature:

With ammonia; In dichloromethane;

DOI:10.1021/jm061094b

Reference yield: 47.0%

N,N-dimethylacetamide dimethyl acetal (18871-66-4) + 6-fluoro-2-iodobenzamide (676445-27-5) → 5-(2-fluoro-6-iodophenyl)-3-methyl-1,2,4-oxadiazole (578729-12-1)

Guidance literature:

N,N-dimethylacetamide dimethyl acetal; 6-fluoro-2-iodobenzamide; at 120 ℃; for 5h;

With sodium hydroxide; hydroxylamine hydrochloride; acetic acid; In 1,4-dioxane; at 60 - 90 ℃; for 5h;

DOI:10.1021/jm061094b

upstream raw materials:

2-fluoro-6-iodobenzoyl chloride

2-fluoro-6-iodobenzoic acid

Downstream raw materials:

5-(2-fluoro-6-iodophenyl)-3-methyl-1,2,4-oxadiazole

tert-butyl (1R)-1-[3,3'-difluoro-2'-(3-methyl-1,2,4-oxadiazol-5-yl)-1,1'-biphenyl-4-yl]-ethylcarbamate

C₁₀H₁₁IN₂O