1-(4-Phenyl-4-piperidyl)propan-1-one hydrochloride

Base Information

• Chemical Name: 1-(4-Phenyl-4-piperidyl)propan-1-one hydrochloride
• CAS No.: 15847-64-0
• Molecular Formula: C14H19 N O . Cl H
• Molecular Weight: 253.772
• Hs Code.: 2933399090
• European Community (EC) Number: 239-959-7
• NSC Number: 57802
• DSSTox Substance ID: DTXSID50166428
• Mol file: 15847-64-0.mol

Synonyms:15847-64-0;1-(4-phenylpiperidin-4-yl)propan-1-one hydrochloride;1-(4-Phenyl-4-piperidyl)propan-1-one hydrochloride;4-Phenyl-4-propionylpiperidine hydrochloride;Ethyl norpethidinate hydrochloride;EINECS 239-959-7;1-Propanone, 1-(4-phenyl-4-piperidinyl)-, hydrochloride;1-(4-phenylpiperidin-4-yl)propan-1-one;hydrochloride;4-Piperidinecarbocylic acid, 4-phenyl-, ethyl ester, hydrochloride;1-Propanone, 1-(4-phenyl-4-piperidinyl)-, hydrochloride (1:1);SCHEMBL1309302;DTXSID50166428;NSC57802;NSC 57802;NSC-57802;AKOS024323058;LS-123159;FT-0744792;1-(4-phenyl-4-piperidinyl)-1-propanone hydrochloride

Chemical Property of 1-(4-Phenyl-4-piperidyl)propan-1-one hydrochloride

Chemical Property:

• Vapor Pressure: 8.85E-05mmHg at 25°C
• Melting Point: 208.8-211.0 °C(Solv: ethyl acetate (141-78-6); ethanol (64-17-5))
• Boiling Point: 340°Cat760mmHg
• Flash Point: 126.2°C
• PSA: 29.10000
• Density: g/cm³
• LogP: 3.41770
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 253.1233420
• Heavy Atom Count: 17
• Complexity: 237

Purity/Quality:

98%min ^*data from raw suppliers

4-PHENYL-4-PROPIONYLPIPERIDINE HYDROCHLORIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(=O)C1(CCNCC1)C2=CC=CC=C2.Cl

Technology Process of 1-(4-Phenyl-4-piperidyl)propan-1-one hydrochloride

There total 1 articles about 1-(4-Phenyl-4-piperidyl)propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-phenyl-4-propionyl-1-(toluene-4-sulfonyl)-piperidine (22940-56-3) → 1-(4-phenyl-[4]piperidyl)-propan-1-one; hydrochloride (15847-64-0)

Guidance literature:

4-phenyl-4-propionyl-1-(toluene-4-sulfonyl)-piperidine; With sulfuric acid; water; for 72h; Reflux;

With sodium hydroxide; In water;

With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(4-phenyl-[4]piperidyl)-propan-1-one; hydrochloride (15847-64-0) → tert-butyl 4-phenyl-4-propionylpiperidine-1-carboxylate (1225653-01-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid (378758-70-4) + 1-(4-phenyl-[4]piperidyl)-propan-1-one; hydrochloride (15847-64-0) → 1-(4-ethylcarbonyl-4-phenyl-piperidin-1-yl)-2-(4-chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile;

upstream raw materials:

4-phenyl-4-propionyl-1-(toluene-4-sulfonyl)-piperidine

Downstream raw materials:

tert-butyl 4-phenyl-4-propionylpiperidine-1-carboxylate

Refernces