4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHATE

Base Information

• Chemical Name: 4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHATE
• CAS No.: 81366-72-5
• Molecular Formula: C15H9Cl2NO4P-
• Molecular Weight: 369.1166
• Mol file: 81366-72-5.mol

Synonyms:4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate;4-chlorophenyl 5-chloro-8-quinolyl phosphate;4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHONATE;

Chemical Property of 4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHATE

Chemical Property:

• Vapor Pressure: 3.14E-12mmHg at 25°C
• Boiling Point: 533.9°Cat760mmHg
• Flash Point: 276.7°C
• PSA: 78.46000
• Density: g/cm³
• LogP: 5.09980

Purity/Quality:

99%min ^*data from raw suppliers

4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHATE

There total 5 articles about 4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Phosphorochloridic acid 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester (77181-80-7) → 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate (81366-72-5)

Guidance literature:

With pyridine; at 0 ℃; for 5h;

DOI:10.1246/cl.1982.197

Reference yield:

5-Chloro-8-hydroxyquinoline (130-16-5) → 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate (81366-72-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 1.) 30 min., -10 deg C; 2.) 45 min, RT;

2: Et₃N

3: tetrahydrofuran / 0.25 h

4: aqueous pyridine

With pyridine; triethylamine; In tetrahydrofuran;

DOI:10.1246/cl.1982.197

Reference yield:

4-chlorophenylphosphorodichloridate (772-79-2) → 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate (81366-72-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 1.) 30 min., -10 deg C; 2.) 45 min, RT;

2: Et₃N

3: tetrahydrofuran / 0.25 h

4: aqueous pyridine

With pyridine; triethylamine; In tetrahydrofuran;

DOI:10.1246/cl.1982.197

upstream raw materials:

Phosphorochloridic acid 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester

4-chlorophenyl 5-chloro-8-quinolyl phosphorotetrazolide

5-Chloro-8-hydroxyquinoline

4-chlorophenylphosphorodichloridate

Downstream raw materials:

Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester

Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

C₅₁H₄₇ClN₄O₁₂P^(1-)

5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-uridine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)

Refernces