77181-80-7

Upstream product

• 130-16-5 5-Chloro-8-hydroxyquinoline 
• 772-79-2 4-chlorophenylphosphorodichloridate 

Downstream Products

• 77181-81-8 4-chlorophenyl 5-chloro-8-quinolyl phosphorotetrazolide 
• 109049-52-7 Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 
• 109049-53-8 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 
• 81366-72-5 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate 
• 75933-79-8 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-uridine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate) 
• 75933-80-1 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁶-benzoyladenosine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate) 
• 75933-82-3 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylguanosine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate) 
• 75933-81-2 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate) 
• 75933-85-6 C₅₁H₄₇ClN₄O₁₂P^(1-) 
• 80015-65-2 Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 
• 83906-28-9 C₆₄H₆₀ClN₄O₁₉P 
• 75933-87-8 Phosphoric acid 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 
• 75933-88-9 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 
• 75933-86-7 Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 

Relevant academic research and scientific papers

SYNTHESIS OF 2'- OR 3'-O-(4-METHOXYBENZYL)NUCLEOSIDES AND ITS APPLICATION IN THE 3'-TERMINAL NONANUCLEOTIDE SEQUENCE OF ROUS SARCOMA VIRUS 35S RNA SYNTHESIS

2'- or 3'-O-(4-Methoxybenzyl)nucleoside derivatives were synthesized by treatment of uridine, N4-benzoylcytidine, N6-benzoyladenosine, and N2-benzoylguanosine with 4-methoxyphenyldiazomethane.The separation of 2'- or 3'- i

Synthesis of Ribooligonucleotides Using the 4-Methoxybenzyl Group as a New Protecting Group for the 2'-Hydroxyl Group

The 4-methoxybenzyl group was introduced to protect the 2'-hydroxyl group of uridine, cytidine, and N2-benzoylguanosine by treatment of 2',3'-O-(dibutylstannylene)uridine or NaH-treated nucleosides with 4-methoxybenzyl bromide.The 2'-O-(4-methoxybenzyl)nucleosides can be used as useful starting materials for the synthesis of 3',5'-linked ribooligonucleotides.The 4-methoxybenzyl group was removed rapidly from the ribooligonucleotides by treatment with triphenylmethyl fluoroborate, and the completely deblocked ribooligonucleotides were characterized by enzymatic hydrolysis.

4-CHLOROPHENYL 5-CHLORO-8-QUINOLYL HYDROGEN PHOSPHATE: A USEFUL PHOSPHORYLATING AGENT FOR GUANOSINE 3'-PHOSPHOTRIESTER

5'-O-Dimethoxytrityl-2'-O-tetrahydropyranyl-N2-benzoylguanosine smoothly reacts with 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate in the presence of 8-quinolinesulfonyltetrazolide (QS-te) to give 5'-O-dimethoxytrityl-2'-O-tetrahydropyr

(8-Quinolinesulfonyl)tetrazole: A New Type of Highly Efficient Coupling Agent for the Synthesis of Ribooligonucleotides by the Phosphortriester Approach

(8-Quinolinesulfonyl)Tetrazole (QS-tet) has been developed as a new type of highly efficient coupling agent in the synthesis of phosphotriester bonds.This reagent very rapidly completes the coupling reactions, and the yield is considerably higher than tha