(3R,4R)-3-Amino-1-hydroxy-4-methylpyrrolidin-2-one

Base Information

Chemical Name:(3R,4R)-3-Amino-1-hydroxy-4-methylpyrrolidin-2-one
CAS No.:130931-65-6
Molecular Formula:C₅H₁₀N₂O₂
Molecular Weight:130.147
Hs Code.:
DSSTox Substance ID:DTXSID00437953
Nikkaji Number:J446.019G
Wikidata:Q82253560
ChEMBL ID:CHEMBL283819
Mol file:130931-65-6.mol

Synonyms:cis-4-methyl-HA-966;L 687,414;L 687414;L 687414, (3R-cis)-isomer;L-687,414;L-687414

Suppliers and Price of (3R,4R)-3-Amino-1-hydroxy-4-methylpyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(3R,4R)-3-AMINO-1-HYDROXY-4-METHYLPYRROLIDIN-2-ONE 95.00%
5MG
$ 504.34

Total 7 raw suppliers

Chemical Property of (3R,4R)-3-Amino-1-hydroxy-4-methylpyrrolidin-2-one

Chemical Property:

PSA：66.56000
LogP:-0.18060
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:130.074227566
Heavy Atom Count:9
Complexity:137

Purity/Quality:

95+% ^*data from raw suppliers

(3R,4R)-3-AMINO-1-HYDROXY-4-METHYLPYRROLIDIN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CN(C(=O)C1N)O
Isomeric SMILES:C[C@@H]1CN(C(=O)[C@@H]1N)O

Technology Process of (3R,4R)-3-Amino-1-hydroxy-4-methylpyrrolidin-2-one

There total 38 articles about (3R,4R)-3-Amino-1-hydroxy-4-methylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 130865-72-4
(3R,4R) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

: 130931-65-6
(3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one

Guidance literature:: With hydrogen; acetic acid; palladium dihydroxide; In methanol; for 2h; under 2585.7 Torr;
DOI:10.1016/S0040-4020(01)88493-3

Reference yield:

: cis-3-hydrazino-1-benzyloxy-4-methylpyrrolidin-2-one

: 130931-65-6
(3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one

Guidance literature:: palladium; In ethanol; water; acetic acid;

Reference yield:

: 130865-67-7
1-benzyloxy-4-methylpyrrolidin-2-one

: 130931-65-6
(3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / potassium bis-trimethylsilylamide, Davis's oxaziridine = Ph-C(O)-N-SO₂Ph / tetrahydrofuran; toluene / 0.5 h / -100 - -91 °C

2: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C, 30 min, 2) 45 min

3: 78 percent

4: 1) hydrogen, acetic acid, 2) potassium carbonate / 1) platinum(VI) oxide / 1) ethyl acetate, 1 atm, 14 h, 2) methanol, 3 h

5: 90 percent / hydrogen, acetic acid / Pd(OH)2 / C / methanol / 2 h / 2585.7 Torr

With hydrogen; potassium hexamethylsilazane; potassium carbonate; acetic acid; dimethyl sulfoxide; N-(benzenesulfonyl)-3-phenyloxaziridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; palladium dihydroxide; platinum(VI) oxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/S0040-4020(01)88493-3