130865-72-4

Usage

Uses

Used in Pharmaceutical and Fine Chemicals Production:
(3R,4R) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone is used as a building block in the synthesis of pharmaceuticals and other fine chemicals, leveraging its unique structure and functional groups to create a variety of compounds with specific therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3R,4R) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone is used as a key intermediate for the development of new drugs. Its stereochemistry and functional groups can be manipulated to design molecules with desired biological activities, potentially leading to the creation of novel therapeutic agents.
Used in Drug Development:
(3R,4R) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone plays a role in drug development as a structural component that can be optimized for specific pharmacological targets. Its incorporation into drug candidates may enhance their efficacy, selectivity, or pharmacokinetic properties, contributing to the advancement of new treatments for various diseases and conditions.

Upstream product

• 130865-67-7 1-benzyloxy-4-methylpyrrolidin-2-one 
• 132559-84-3 1-benzyloxy-3-hydroxy-4-methyl-2-pyrrolidinone 
• 130865-70-2 1-benzyloxy-4-methyl-pyrrolidine-2,2-dione 
• 100-39-0 benzyl bromide 
• 584-08-7 potassium carbonate 
• 130865-71-3 (R) 1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole 
• 144564-41-0 4-Benzyloxyamino-3-methyl-butyric acid ethyl ester 
• 130865-74-6 4-[(E)-Benzyloxyimino]-3-methyl-butyric acid ethyl ester 
• 70423-44-8 (Z)-4,4-Dimethoxy-3-methyl-crotonsaeureaethylester 
• 114839-28-0 4,4-Dimethoxy-3-methyl-butyric acid ethyl ester 
• 54998-57-1 ethyl 3-formylbutyrate 

Downstream Products

• 1072933-71-1 (3R,4R)-1-hydroxy-3-amino-4-methyl-2-pyrrolidone acetate 
• 130931-65-6 (3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one 

Relevant academic research and scientific papers

A method for utilizing non-chiral auxiliaries diastereoisomer splitting of the new method (by machine translation)

The present invention provides a kind of anti-tumor, anti-seizure and cerebral ischemia such as model drug intermediate using chiral auxiliaries diastereoisomer splitting of the new method; adopts the cheap achiral inorganic acid precursor with the target

A short and efficient synthesis of the NMDA glycine site antagonist: (3R,4R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414)

A short and efficient synthesis of the NMDA glycine site antagonist: (3R,4R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414) is described.

Routes to 4-Substituted Analogues of the Glycine/NMDA Antagonist HA-966. Enantioselective Synthesis of (3R,4R) 3-Amino-1-Hydroxy-4-Methyl-2-Pyrrolidinone (L-687,414).

Glycine anion (4) and glycine cation (8) synthons are used in efficient synthesis of 4-substituted analogues of HA-966 (1).A stereospecific route to cis derivatives involves hydrogenation of enamines such as 16.Introduction of a chiral auxiliary leads to

Hydrocarbon substituted pyrrolidinones, intermediates therefor, and anti-convulsant use thereof

Compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof: STR1 wherein R represents a hydrocarbon group, X represents oxygen or sulphur, and R and --NH2 are cis; are of use in the treatment and/or prevention of neuro