Acetamide, 2,2,2-trifluoro-N-[3-(phenylethynyl)-2-quinoxalinyl]-

Base Information

Chemical Name:Acetamide, 2,2,2-trifluoro-N-[3-(phenylethynyl)-2-quinoxalinyl]-
CAS No.:676543-67-2
Molecular Formula:C18H10F3N3O
Molecular Weight:341.292
Hs Code.:
DSSTox Substance ID:DTXSID70460692
Nikkaji Number:J2.022.352I
Wikidata:Q82284840

Synonyms:676543-67-2;2,2,2-Trifluoro-N-(3-(phenylethynyl)quinoxalin-2-yl)acetamide;2,2,2-trifluoro-N-[3-(2-phenylethynyl)quinoxalin-2-yl]acetamide;Acetamide, 2,2,2-trifluoro-N-[3-(phenylethynyl)-2-quinoxalinyl]-;DTXSID70460692

Suppliers and Price of Acetamide, 2,2,2-trifluoro-N-[3-(phenylethynyl)-2-quinoxalinyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Acetamide, 2,2,2-trifluoro-N-[3-(phenylethynyl)-2-quinoxalinyl]-

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:341.07759644
Heavy Atom Count:25
Complexity:545

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C#CC2=NC3=CC=CC=C3N=C2NC(=O)C(F)(F)F

Technology Process of Acetamide, 2,2,2-trifluoro-N-[3-(phenylethynyl)-2-quinoxalinyl]-

There total 5 articles about Acetamide, 2,2,2-trifluoro-N-[3-(phenylethynyl)-2-quinoxalinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 407-25-0
trifluoroacetic anhydride

: 361390-32-1
2-amino-3-phenylethynylquinoxaline

: 676543-67-2
2,2,2-trifluoro-N-(3-phenylethynyl-quinoxalin-2-yl)-acetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1055/s-2003-45004

Reference yield:

: 23719-78-0
2,3-dibromo-quinoxaline

: 676543-67-2
2,2,2-trifluoro-N-(3-phenylethynyl-quinoxalin-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / aq. NH₄OH; K₂CO₃ / dimethylsulfoxide; acetonitrile / 120 h / 50 °C

2: 85 percent / Et₂NH; CuI / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 40 °C

3: 100 percent / Et₃N / tetrahydrofuran / 1.5 h / 20 °C

With ammonium hydroxide; copper(l) iodide; potassium carbonate; diethylamine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-2003-45004

Reference yield:

: 676543-54-7
2-amino-3-bromoquinoxaline

: 676543-67-2
2,2,2-trifluoro-N-(3-phenylethynyl-quinoxalin-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Et₂NH; CuI / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 40 °C

2: 100 percent / Et₃N / tetrahydrofuran / 1.5 h / 20 °C

With copper(l) iodide; diethylamine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-45004