676543-54-7

Usage

General Description

2-Amino-3-bromoquinoxaline is a chemical compound with the molecular formula C9H6BrN3. It is a heterocyclic aromatic compound with a quinoxaline backbone, containing a bromine substituent at the 3-position and an amino group at the 2-position. This chemical is widely used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds and drug candidates. It is also used in research and development for its potential applications in medicinal chemistry and drug discovery. 2-Amino-3-bromoquinoxaline has shown promise in the development of new therapies for a range of diseases and conditions, making it an important and valuable chemical in medicinal chemistry and drug development.

Upstream product

• 23719-78-0 2,3-dibromo-quinoxaline 
• 15804-19-0 2,3-dihydroxyquinoxaline 
• 95-54-5 1,2-diamino-benzene 
• 15804-19-0 quinoxaline-2,3-dione 

Downstream Products

• 685905-64-0 3-(3-methoxy-phenylethynyl)-quinoxalin-2-ylamine 
• 1186469-69-1 3-(5-phenyl-2-oxazolyl)-2-quinoxalinamine 
• 685905-67-3 2,2,2-trifluoro-N-[3-(3-methoxy-phenylethynyl)-quinoxalin-2-yl]-acetamide 
• 685905-66-2 2,2,2-trifluoro-N-[3-(4-methoxy-phenylethynyl)-quinoxalin-2-yl]-acetamide 
• 64802-09-1 2-Phenyl<1H>pyrrolo<2,3-b>quinoxaline 
• 685905-63-9 3-(4-methoxy-phenylethynyl)-quinoxalin-2-ylamine 
• 361390-32-1 2-amino-3-phenylethynylquinoxaline 
• 676543-67-2 2,2,2-trifluoro-N-(3-phenylethynyl-quinoxalin-2-yl)-acetamide 

Relevant academic research and scientific papers

Indolizino[5,6-b]quinoxaline Derivatives: Intramolecular Charge Transfer Characters and NIR Fluorescence

Indolizino[5,6-b]quinoxaline derivatives (1 a and 1 b) with a push-pull structure were prepared to show intramolecular charge-transfer properties. Compounds 1 a and 1 b are strongly fluorescent in aprotic solvents while symmetrical derivatives (2 a and 2 b) were non-fluorescent. The π-expanded α-α linked dimer (10) of indolizino[5,6-b]quinoxaline 1 b was serendipitously obtained to show NIR absorption over 800 nm and the fluorescence edge reached to 1400 nm.

AMINO-QUINOXALINE AND AMINO-QUINOLINE COMPOUNDS FOR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS

Compounds of the Formula (I), where W represents CH or N; and Q represents -CN, -C(=NOH)NH2, -CONHR1 or various herein described heterocyclic radicals; as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson''s disease.

2,3-Disubstituted pyrrolo[2,3-b]quinoxalines via aminopalladation- reductive elimination

2,3-Disubstituted pyrrolo[2,3-b]quinoxalines have been prepared in good to high yield through the reaction of 2-alkynyl-3-trifluoroacetamidoquinoxalines with aryl and vinyl halides or triflates in the presence of Pd(PPh 3)4 and K2CO3 in MeCN at 100°C.

2-Aryl and 2-Heteroaryl Pyrrolo[2,3-b]quinoxalines via Copper-Catalyzed Reaction of 1-Alkynes with 2-Bromo-3-trifluoroacetamidoquinoxaline

2-Aryl and 2-heteroaryl pyrrolo[2,3-b]quinoxalines have been prepared in good to high yield through the reaction of 1-alkynes with 2-bromo-3- trifluoroacetamidoquinoxaline in the presence of catalytic amounts of CuI, PPh3, and K2CO3 in dioxane at 110°C. The reaction appears to tolerate a wide range of functionalized 1-alkynes, including those containing ether, alcohol, amide, aldehyde, ketone, ester, and nitro groups.