Technology Process of 1-Oxa-2-silacyclopentane,
3-[[(4S,6R)-6-[(1E,3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-1
-hexenyl]-2,2-dimethyl-1,3-dioxan-4-yl]methylene]-5-[(2S)-2-[(4-methoxy
phenyl)methoxy]-4-(trimethylsilyl)-3-butynyl]-2,2-dimethyl-, (3E,5S)-
There total 14 articles about 1-Oxa-2-silacyclopentane,
3-[[(4S,6R)-6-[(1E,3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-1
-hexenyl]-2,2-dimethyl-1,3-dioxan-4-yl]methylene]-5-[(2S)-2-[(4-methoxy
phenyl)methoxy]-4-(trimethylsilyl)-3-butynyl]-2,2-dimethyl-, (3E,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(η2:η2-1,3-divinyltetramethyl)platinum(0);
In
tetrahydrofuran; xylene;
at 20 ℃;
for 21h;
DOI:10.1021/ja039618+
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 74 percent / 10-camphorsulfonic acid / CH2Cl2 / 96 h
2.1: 79 percent / m-chloroperbenzoic acid / CH2Cl2 / 6 h / 20 °C
3.1: 42 percent / (S,S)-salen Co(III)OAc polymer-supported catalyst / tetrahydrofuran / 22 h / 20 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 2.5 h / -60 - -40 °C
4.2: BF3*Et2O / tetrahydrofuran; hexane / 0.25 h / -78 °C
4.3: 82 percent / tetrahydrofuran; hexane / 1.5 h / -78 °C
5.1: 15 h / 100 °C
6.1: Pt(DVDS) / tetrahydrofuran; xylene / 21 h / 20 °C
With
n-butyllithium; bis(η2:η2-1,3-divinyltetramethyl)platinum(0); (S,S)-salen Co(III)OAc polymer-supported catalyst; (1S)-10-camphorsulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; hexane; dichloromethane; xylene;
DOI:10.1021/ja039618+
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: NaH / diethyl ether / 0.5 h
1.2: diethyl ether / 1.5 h / 20 °C
2.1: 74 percent / 10-camphorsulfonic acid / CH2Cl2 / 96 h
3.1: 79 percent / m-chloroperbenzoic acid / CH2Cl2 / 6 h / 20 °C
4.1: 42 percent / (S,S)-salen Co(III)OAc polymer-supported catalyst / tetrahydrofuran / 22 h / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 2.5 h / -60 - -40 °C
5.2: BF3*Et2O / tetrahydrofuran; hexane / 0.25 h / -78 °C
5.3: 82 percent / tetrahydrofuran; hexane / 1.5 h / -78 °C
6.1: 15 h / 100 °C
7.1: Pt(DVDS) / tetrahydrofuran; xylene / 21 h / 20 °C
With
n-butyllithium; bis(η2:η2-1,3-divinyltetramethyl)platinum(0); (S,S)-salen Co(III)OAc polymer-supported catalyst; (1S)-10-camphorsulfonic acid; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; xylene;
DOI:10.1021/ja039618+
![(4S,6R)-4-[(4R,6S)-4-Dimethylsilanyloxy-6-(4-methoxy-benzyloxy)-8-trimethylsilanyl-octa-1,7-diynyl]-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2,2-dimethyl-[1,3]dioxane](/Databaselist/images/loading.webp)
