Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Base Information

Chemical Name:Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
CAS No.:676560-16-0
Molecular Formula:C13H26O3Si
Molecular Weight:258.433
Hs Code.:

Synonyms:4-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid;4-(tert-butyldimethylsilanoxy)cyclohexanecarboxylic acid;4-(dimethyl-tert-butyl-silyl)oxycyclohexane-1-carboxylic acid;

Suppliers and Price of Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Chemical Property:

PSA：46.53000
LogP:3.65160

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

There total 5 articles about Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 676560-15-9
Ethyl (cis/trans)-4-<(tert-butyldimethylsilyl)oxy>cyclohexanecarboxylate

: 676560-16-0
4-[(tert-butyldimethylsilyl)oxy]cyclohexane-1-carboxylic acid

Guidance literature:: Ethyl (cis/trans)-4-<(tert-butyldimethylsilyl)oxy>cyclohexanecarboxylate; With sodium hydroxide; water; In tetrahydrofuran; at 20 - 70 ℃; for 72h;

With citric acid; In water; pH=~ 5;

Reference yield:

: 3685-22-1,3685-26-5,17419-81-7
4-hydroxycyclohexanecarboxylic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 676560-16-0
4-[(tert-butyldimethylsilyl)oxy]cyclohexane-1-carboxylic acid

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 676560-16-0
4-[(tert-butyldimethylsilyl)oxy]cyclohexane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: lithium hydroxide / methanol; tetrahydrofuran / 20 °C

With 1H-imidazole; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2016.05.040