(2S,5S)-1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,5S)-1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate
CAS No.:676560-83-1
Molecular Formula:C13H23NO4
Molecular Weight:257.33
Hs Code.:
Mol file:676560-83-1.mol

Synonyms:(2R,5S)-1-tert-butyl 2-ethyl-5-methylpyrrolidine-1,2-dicarboxylate;5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester;Boc-5(S)-methyl-L-proline ethyl ester;(2S,5S)-1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate;

Suppliers and Price of (2S,5S)-1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (2S,5S)-1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate

Chemical Property:

PSA：55.84000
LogP:2.27540

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,5S)-1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate

There total 9 articles about (2S,5S)-1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 676560-84-2,166941-67-9
(2S,5S)-5-methylpyrrolidine-2-carboxylic acid ethyl ester

: 676560-83-1
(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 24h;

Reference yield:

: 896733-29-2
(S)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 676560-83-1
(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Guidance literature:: (S)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester; With palladium 10% on activated carbon; hydrogen; In ethanol; at 35 ℃; under 2844.39 Torr;

di-tert-butyl dicarbonate; With dmap; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 913251-58-8
(S)-2-(tert-butoxycarbonylamino)-5-oxohexanoic acid ethyl ester

: 676560-83-1
(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CF₃COOH / CH₂Cl₂ / 3 h / 20 °C

2: H₂ / Pd/C / ethanol / 20 °C / 3102.89 Torr

3: 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 20 °C

With dmap; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm051283e