PIPERIDIN-3-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCl

Base Information

• Chemical Name: PIPERIDIN-3-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCl
• CAS No.: 676621-99-1
• Molecular Formula: C14H20N2O2.ClH
• Molecular Weight: 284.786
• Hs Code.: 2933399090
• Mol file: 676621-99-1.mol

Synonyms:Benzyl (3-piperidinylmethyl)carbamate hydrochloride (1:1);

Chemical Property of PIPERIDIN-3-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCl

Chemical Property:

• PSA: 53.85000
• LogP: 3.24760

Purity/Quality:

99%min ^*data from raw suppliers

Benzyl(piperidin-3-ylmethyl)carbamatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDIN-3-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCl

There total 3 articles about PIPERIDIN-3-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-(benzyloxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester (478366-01-7) → 3-(benzyloxycarbonylaminomethyl)-piperidine hydrochloride (676621-99-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 1.33333h;

Reference yield:

tert-butyl 3-(aminomethyl)piperidine-1-carboxylate (162167-97-7) → 3-(benzyloxycarbonylaminomethyl)-piperidine hydrochloride (676621-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 0 - 15 °C

2: hydrogenchloride / water monomer; ethyl acetate / 12 h / 15 °C

With hydrogenchloride; triethylamine; In dichloromethane; water monomer; ethyl acetate;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 3-(benzyloxycarbonylaminomethyl)-piperidine hydrochloride (676621-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 0 - 15 °C

2: hydrogenchloride / water monomer; ethyl acetate / 12 h / 15 °C

With hydrogenchloride; triethylamine; In dichloromethane; water monomer; ethyl acetate;

upstream raw materials:

3-(benzyloxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-(aminomethyl)piperidine-1-carboxylate

benzyl chloroformate

Downstream raw materials:

{1-[2-(4-Fluorophenyl)ethyl]-piperidin-3-ylmethyl}carbamic Acid Benzyl Ester

Refernces

• 1、 -. "QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS". Page/Page column 241. . Retrieved 2008/06/13.