Benzoic acid, 4-[[2-fluoro-3-methoxy-6-(methoxymethoxy)phenyl][[tris(1-methylethyl)sil yl]oxy]methyl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 4-[[2-fluoro-3-methoxy-6-(methoxymethoxy)phenyl][[tris(1-methylethyl)sil yl]oxy]methyl]-, methyl ester
CAS No.:677323-84-1
Molecular Formula:C27H39FO6Si
Molecular Weight:506.687
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 4-[[2-fluoro-3-methoxy-6-(methoxymethoxy)phenyl][[tris(1-methylethyl)sil yl]oxy]methyl]-, methyl ester

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Technology Process of Benzoic acid, 4-[[2-fluoro-3-methoxy-6-(methoxymethoxy)phenyl][[tris(1-methylethyl)sil yl]oxy]methyl]-, methyl ester

There total 1 articles about Benzoic acid, 4-[[2-fluoro-3-methoxy-6-(methoxymethoxy)phenyl][[tris(1-methylethyl)sil yl]oxy]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13154-24-0
triisopropylsilyl chloride

: 677323-83-0
4-[(2-fluoro-3-methoxy-6-methoxymethoxy-phenyl)-hydroxy-methyl]-benzoicacidmethylester

: 677323-84-1
4-[(2-fluoro-3-methoxy-6-methoxymethoxyphenyl)-(1,1,1-triisopropylsilanyloxy)methyl]benzoic acid methyl ester

Guidance literature:: triisopropylsilyl chloride; 4-[(2-fluoro-3-methoxy-6-methoxymethoxy-phenyl)-hydroxy-methyl]-benzoicacidmethylester; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

With triisopropylsilyl trifluoromethanesulfonate; In N,N-dimethyl-formamide; at 100 ℃; for 36h;
DOI:10.1021/jm0310479

Reference yield: 70.0%

: 677323-84-1
4-[(2-fluoro-3-methoxy-6-methoxymethoxyphenyl)-(1,1,1-triisopropylsilanyloxy)methyl]benzoic acid methyl ester

: 677323-85-2
{4-[(2-fluoro-3-methoxy-6-methoxymethoxyphenyl)-(1,1,1-triisopropylsilanyloxy)methyl]phenyl}methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm0310479

Reference yield:

: 677323-84-1
4-[(2-fluoro-3-methoxy-6-methoxymethoxyphenyl)-(1,1,1-triisopropylsilanyloxy)methyl]benzoic acid methyl ester

: 677323-89-6
(3R,4R)-4-[4-(2-fluoro-3-methoxy-6-methoxymethoxybenzoyl)benzyloxy]-3-[(pyridine-4-carbonyl)amino]azepane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 70 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

2.1: 74 percent / PPh₃; CCl₄ / 3 h / 20 °C

3.1: 43 percent / tetrahydrofuran / 2 h / Heating

4.1: 92 percent / DMAP; DCC / CH₂Cl₂ / 15 h / 20 °C

5.1: Bu₄NF*4H₂O / tetrahydrofuran / 15 h / 20 °C

5.2: MnO₂ / CH₂Cl₂ / 24 h / 20 °C

With tetrachloromethane; dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0310479