Chlorfluren-methyl

Base Information

Chemical Name:Chlorfluren-methyl
CAS No.:22909-50-8
Molecular Formula:C₁₅H₁₁ClO₂
Molecular Weight:258.704
Hs Code.:
UNII:S2ER2O1U4O
DSSTox Substance ID:DTXSID70945590
Nikkaji Number:J22.068J
Wikidata:Q27288491
Mol file:22909-50-8.mol

Synonyms:Chlorfluren-methyl;Chlorfluren-methyl [ISO];22909-50-8;UNII-S2ER2O1U4O;S2ER2O1U4O;IT-5732;MORPHACTIN IT-5732;SCHEMBL1981762;DTXSID70945590;BAY-102613;methyl 2-chloro-9H-fluorene-9-carboxylate;METHYL 2-CHLORO-9-FLUORENECARBOXYLATE;Q27288491;9H-FLUORENE-9-CARBOXYLIC ACID, 2-CHLORO-, METHYL ESTER

Suppliers and Price of Chlorfluren-methyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Chlorfluren-methyl

Chemical Property:

Vapor Pressure:5.87E-06mmHg at 25°C
Boiling Point:379.4°Cat760mmHg
Flash Point:197.9°C
PSA：26.30000
Density:1.307g/cm³
LogP:3.62530
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:258.0447573
Heavy Atom Count:18
Complexity:331

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1C2=CC=CC=C2C3=C1C=C(C=C3)Cl

Technology Process of Chlorfluren-methyl

There total 6 articles about Chlorfluren-methyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1329489-24-8
methyl 2-(4'-chlorobiphenyl-2-yl)diazoacetate

: 22909-50-8
2-chlorofluorene-9-carboxylic acid methyl ester

Guidance literature:: With dirhodium tetraacetate; In 1,2-dichloro-ethane; at 25 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1002/asia.201100142

Reference yield:

: 1329489-84-0
methyl 2-(4'-chlorobiphenyl-2-yl)acetate

: 22909-50-8
2-chlorofluorene-9-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-acetamidobenzenesulfonyl azide / tetrahydrofuran / 0.08 h / Inert atmosphere

1.2: 12 h / 25 °C / Inert atmosphere

2.1: dirhodium tetraacetate / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere

With dirhodium tetraacetate; 4-acetamidobenzenesulfonyl azide; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1002/asia.201100142

Reference yield:

: 18698-97-0
ortho-bromophenylacetic acid

: 22909-50-8
2-chlorofluorene-9-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 3 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.08 h

2.2: 12 h / 100 °C

3.1: 4-acetamidobenzenesulfonyl azide / tetrahydrofuran / 0.08 h / Inert atmosphere

3.2: 12 h / 25 °C / Inert atmosphere

4.1: dirhodium tetraacetate / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere

With hydrogenchloride; dirhodium tetraacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-acetamidobenzenesulfonyl azide; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; 2.2: Suzuki-Miyaura coupling;
DOI:10.1002/asia.201100142