Benzamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

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Chemical Name:Benzamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-
CAS No.:678144-93-9
Molecular Formula:C39H46N4O4S2
Molecular Weight:698.951
Hs Code.:

Benzamide,
N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien
yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

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Chemical Property of Benzamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

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Technology Process of Benzamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

There total 5 articles about Benzamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 98-88-4
benzoyl chloride

: 678144-87-1
N-tert-butyl-3-(4-{[6-(ethylamino)-4-oxo-2-propyl-3,4-dihydroquinazolin-3-yl]methyl}phenyl)-5-isobutylthiophene-2-sulfonamide

: 678144-93-9
N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-N-ethyl-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm031031i

Reference yield:

: 156483-24-8
3-(4-bromobenzyl)-6-nitro-2-propyl-3,4-dihydroquinazolin-4-one

: 678144-93-9
N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-N-ethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 93 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i

Reference yield:

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 678144-93-9
N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-N-ethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 93 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i