2-Cyclopenten-1-one, 4-(2,5-dimethoxy-4-methylphenyl)-4-methyl-

Base Information

Chemical Name:2-Cyclopenten-1-one, 4-(2,5-dimethoxy-4-methylphenyl)-4-methyl-
CAS No.:678149-58-1
Molecular Formula:C15H18O3
Molecular Weight:246.306
Hs Code.:

Synonyms:

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Chemical Property of 2-Cyclopenten-1-one, 4-(2,5-dimethoxy-4-methylphenyl)-4-methyl-

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Technology Process of 2-Cyclopenten-1-one, 4-(2,5-dimethoxy-4-methylphenyl)-4-methyl-

There total 6 articles about 2-Cyclopenten-1-one, 4-(2,5-dimethoxy-4-methylphenyl)-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 678149-57-0
4-methyl-4-(2,5-dimethoxy-4-methylphenyl)cyclopent-2-enol

: 678149-58-1
4-methyl-4-(2,5-dimethoxy-4-methylphenyl)cyclopent-2-enone

Guidance literature:: With sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1055/s-2003-45003

Reference yield:

: 13720-58-6
1-(2,5-Dimethoxy-4-methyl-phenyl)-ethanone

: 678149-58-1
4-methyl-4-(2,5-dimethoxy-4-methylphenyl)cyclopent-2-enone

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / NaH / tetrahydrofuran / 5 h / Heating

2.1: 91 percent / LiAlH₄ / diethyl ether / 2 h / -70 - 20 °C

3.1: EtCOOH / 48 h / 180 °C

3.2: LiAlH₄ / diethyl ether / 2 h / -40 - 20 °C

4.1: 87 percent / PCC-silica gel / CH₂Cl₂ / 1 h / 20 °C

5.1: 88 percent / tetrahydrofuran / 1 h / 20 °C

6.1: 95 percent / PhCH=Ru(Cl)2(PCy₃)2 / CH₂Cl₂ / 4 h / 20 °C

7.1: 86 percent / pyridinium chlorochromate; NaOAc / CH₂Cl₂ / 1 h / 20 °C

With lithium aluminium tetrahydride; pyridinium chlorochromate on silica gel; sodium acetate; sodium hydride; propionic acid; pyridinium chlorochromate; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Horner-Wadsworth-Emmons reaction / 5.1: Grignard reaction;
DOI:10.1055/s-2003-45003

Reference yield:

: 678149-54-7
3-(2,5-dimethoxy-4-methylphenyl)but-2-enol

: 678149-58-1
4-methyl-4-(2,5-dimethoxy-4-methylphenyl)cyclopent-2-enone

Guidance literature:: Multi-step reaction with 5 steps

1.1: EtCOOH / 48 h / 180 °C

1.2: LiAlH₄ / diethyl ether / 2 h / -40 - 20 °C

2.1: 87 percent / PCC-silica gel / CH₂Cl₂ / 1 h / 20 °C

3.1: 88 percent / tetrahydrofuran / 1 h / 20 °C

4.1: 95 percent / PhCH=Ru(Cl)2(PCy₃)2 / CH₂Cl₂ / 4 h / 20 °C

5.1: 86 percent / pyridinium chlorochromate; NaOAc / CH₂Cl₂ / 1 h / 20 °C

With pyridinium chlorochromate on silica gel; sodium acetate; propionic acid; pyridinium chlorochromate; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; 3.1: Grignard reaction;
DOI:10.1055/s-2003-45003