2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(2Z)-3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluor o-5-[(4-methoxyphenyl)diphenylmethoxy]-2-pentenyl]-5-methyl-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(2Z)-3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluor o-5-[(4-methoxyphenyl)diphenylmethoxy]-2-pentenyl]-5-methyl-
CAS No.:678182-86-0
Molecular Formula:C45H51FN2O6Si
Molecular Weight:762.994
Hs Code.:

2,4(1H,3H)-Pyrimidinedione,
3-benzoyl-1-[(2Z)-3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluor
o-5-[(4-methoxyphenyl)diphenylmethoxy]-2-pentenyl]-5-methyl-

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(2Z)-3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluor o-5-[(4-methoxyphenyl)diphenylmethoxy]-2-pentenyl]-5-methyl-

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(2Z)-3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluor o-5-[(4-methoxyphenyl)diphenylmethoxy]-2-pentenyl]-5-methyl-

There total 7 articles about 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(2Z)-3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluor o-5-[(4-methoxyphenyl)diphenylmethoxy]-2-pentenyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 4330-20-5
N-3-benzoylthymine

: 3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pent-2-en-1-ol

: 678182-86-0
3-benzoyl-1-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pent-2-enyl}-5-methyl-1H-pyrimidine-2,4-dione

: 678182-80-4
3-benzoyl-1-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pent-2-enyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃;
DOI:10.1081/NCN-120022833

Reference yield:

: 32328-03-3
diethyl 3-hydroxyglutarate

: 678182-86-0
3-benzoyl-1-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pent-2-enyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: 65 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

2.1: 42 percent / pyridine / 20 °C

3.1: 88 percent / pyridine / 20 °C

4.1: 98 percent / o-iodoxybenzoic acid / dimethylsulfoxide; tetrahydrofuran / 6 h / 20 °C

5.1: n-BuLi / tetrahydrofuran / 2 h / -78 °C

5.2: 70 percent / tetrahydrofuran / 4 h / -78 - 20 °C

6.1: 62 percent / LiAlH₄ / diethyl ether / 2 h / 20 °C

7.1: 35 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; triphenylphosphine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1081/NCN-120022833

Reference yield:

: 4328-94-3
pentane-1,3,5-triol

: 678182-86-0
3-benzoyl-1-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pent-2-enyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 42 percent / pyridine / 20 °C

2.1: 88 percent / pyridine / 20 °C

3.1: 98 percent / o-iodoxybenzoic acid / dimethylsulfoxide; tetrahydrofuran / 6 h / 20 °C

4.1: n-BuLi / tetrahydrofuran / 2 h / -78 °C

4.2: 70 percent / tetrahydrofuran / 4 h / -78 - 20 °C

5.1: 62 percent / LiAlH₄ / diethyl ether / 2 h / 20 °C

6.1: 35 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; triphenylphosphine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1081/NCN-120022833