Synonyms:2-amino-2-imidazoline;2-I-I cpd
99% *data from raw suppliers
KP001141:4,5-Dihydro-1H-imidazol-2-ylamine 95 *data from reagent suppliers
There total 12 articles about 2-Aminoimidazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 100.0%
Reference yield: 80.0%
Reference yield: 78.0%
The study focuses on the synthesis and pharmacological activity of guanidine and 2-aminoimidazoline derivatives, which are of interest for their potential as new hypotensive agents. Key chemicals involved include N,N-dimethyl-N-dichloromethylene-immonium chloride (I) and N,N-dimethyl-N'-(2,6-dichlorophenyl)-C-chloroformamidine hydrochloride (II), used as starting compounds. The researchers synthesized various derivatives such as N-substituted N'-(2,6-dichlorophenyl)-N",N"-dimethylguanidines (III) and N,N-dimethyl-N'-(4,6-dichloro-5-pyrimidyl)-C-chloroformamidine (V), aiming to explore their potential hypotensive properties. The study also involved the creation of 2-aminoimidazoline derivatives (VII, VIII) and their quaternary salts (IXa-c), as well as N-substituted N'-(2,6-dichlorophenyl)-ethylene-ureas (Xa, b) and the final compound XI. The pharmacological testing revealed that some compounds exhibited a-adrenomimetic action, while others showed ganglio-blocking properties, though none possessed sympatholytic action. The study's findings contribute to the understanding of the relationship between the chemical structure of these compounds and their pharmacological effects.
The research explores the development of di-aryl guanidinium derivatives as potential a2-adrenergic receptor (a2-AR) antagonists for treating depression. The study, conducted by a team from Trinity College Dublin, Stanford University, and the University of the Basque Country, synthesized eighteen di-aryl mono- or di-substituted guanidines and 2-aminoimidazolines. These compounds were tested for their binding affinity and functional activity in human brain tissue. The results showed that compounds with a di-arylmethylene core, a 2-aminoimidazolinium cation, and a di-substituted guanidinium exhibited high a2-AR binding affinity. Compounds 7a, 7b, and 7c were identified as partial agonists, while 8h was a potent antagonist. Molecular modeling and docking studies suggested that antagonism is achieved by compounds with a di-substituted guanidine that occupies a pocket adjacent to TM5 without engaging specific residues, while a mono-substituted cationic group interacts favorably with E942.65.
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