N,N-dibenzylglycine

Base Information

• Chemical Name: N,N-dibenzylglycine
• CAS No.: 65130-70-3
• Molecular Formula: C₁₆H₁₇NO₂*ClH
• Molecular Weight: 291.777
• Mol file: 65130-70-3.mol

Synonyms:Glycine,N,N-dibenzyl-, hydrochloride (6CI)

Chemical Property of N,N-dibenzylglycine

Chemical Property:

• Vapor Pressure: 5.76E-07mmHg at 25°C
• Boiling Point: 395.5°C at 760 mmHg
• Flash Point: 193°C
• PSA: 40.54000
• Density: 1.171g/cm³
• LogP: 3.57540

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dibenzylglycine

There total 1 articles about N,N-dibenzylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(dibenzylamino)acetic acid methyl ester (94226-55-8) → N,N-dibenzylglycine hydrochloride (65130-70-3)

Guidance literature:

With lithium hydroxide; In methanol; water; at 0 - 60 ℃; for 18h;

DOI:10.1021/ic5013389

Reference yield: 34.0%

4-hydroxybenzotriazole (26725-51-9) + (2-aminoethyl)bis(2-pyridylmethyl)amine (189440-33-3) + N,N-dibenzylglycine hydrochloride (65130-70-3) → C30H33N5O*ClH

Guidance literature:

4-hydroxybenzotriazole; N,N-dibenzylglycine hydrochloride; With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

(2-aminoethyl)bis(2-pyridylmethyl)amine; In dichloromethane; at 0 - 20 ℃; for 72h; Inert atmosphere;

DOI:10.1021/ic5013389

Reference yield:

piperazine (110-85-0) + Fmoc-Pro-OH (71989-31-6) + N-Fmoc L-Phe (35661-40-6) + N,N-dibenzylglycine hydrochloride (65130-70-3) → C43H50N6O4

Guidance literature:

Multistep reaction.;

DOI:10.1021/ol990624d

upstream raw materials:

(dibenzylamino)acetic acid methyl ester

Refernces