Technology Process of 1,8-Naphthyridine-2-pentanoic acid, 1,5,6,7-tetrahydro-3-phenyl-, ethyl
ester
There total 4 articles about 1,8-Naphthyridine-2-pentanoic acid, 1,5,6,7-tetrahydro-3-phenyl-, ethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
1,2-dimethoxyethane;
at 80 ℃;
for 16h;
DOI:10.1016/j.bmcl.2003.11.036
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / proline / ethanol
2: 82 percent / H2 / Pd/C
3: 100 percent / Br2; AcOH
4: 71 percent / (Ph3P)4Pd; Na2CO3 / 1,2-dimethoxy-ethane / 16 h / 80 °C
With
tetrakis(triphenylphosphine) palladium(0); hydrogen; bromine; sodium carbonate; acetic acid; rac-Pro-OH;
palladium on activated charcoal;
In
1,2-dimethoxyethane; ethanol;
1: Friedlander condensation / 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2003.11.036
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / proline / ethanol
2: 82 percent / H2 / Pd/C
3: 100 percent / Br2; AcOH
4: 71 percent / (Ph3P)4Pd; Na2CO3 / 1,2-dimethoxy-ethane / 16 h / 80 °C
With
tetrakis(triphenylphosphine) palladium(0); hydrogen; bromine; sodium carbonate; acetic acid; rac-Pro-OH;
palladium on activated charcoal;
In
1,2-dimethoxyethane; ethanol;
1: Friedlander condensation / 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2003.11.036
