Technology Process of Piperidine,
1-[2-[4-(2',3'-dihydro-5,5'-dimethoxy-1,1'-spirobi[1H-inden]-3-yl)phenoxy
]ethyl]-
There total 10 articles about Piperidine,
1-[2-[4-(2',3'-dihydro-5,5'-dimethoxy-1,1'-spirobi[1H-inden]-3-yl)phenoxy
]ethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
toluene;
for 0.5h;
Heating;
DOI:10.1021/jm034134+
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tetrahydrofuran / 20 °C
2.1: aq. H2SO4 / dioxane / 6 h / Heating
3.1: 135 g / H2; AcOH / Pd(OH)2/C / 12 h / 20 °C / 760 Torr
4.1: (COCl)2; DMF / toluene / 4 h / 20 °C
5.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C
5.2: tetrahydrofuran; toluene / 1 h / -78 °C
6.1: 106 g / 4-acetoamidobenzenesulfonyl azide; Et3N / acetonitrile / 2 h / 20 °C
7.1: 82 percent / Rh2(OAc)4*H2O / various solvent(s) / 0.5 h / 60 °C
8.1: 100 percent / H2O; dimethylsulfoxide / 1 h / 150 °C
9.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
9.2: tetrahydrofuran; hexane / -78 - 20 °C
10.1: 2.00 g / p-TsOH*H2O / toluene / 0.5 h / Heating
With
n-butyllithium; oxalyl dichloride; Rh2(μ-acetate)4(H2O); sulfuric acid; 4-acetamidobenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; toluene-4-sulfonic acid; acetic acid; triethylamine; N,N-dimethyl-formamide;
palladium dihydroxide;
In
tetrahydrofuran; 1,4-dioxane; hexane; water; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm034134+
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tetrahydrofuran / 20 °C
2.1: aq. H2SO4 / dioxane / 6 h / Heating
3.1: 135 g / H2; AcOH / Pd(OH)2/C / 12 h / 20 °C / 760 Torr
4.1: (COCl)2; DMF / toluene / 4 h / 20 °C
5.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C
5.2: tetrahydrofuran; toluene / 1 h / -78 °C
6.1: 106 g / 4-acetoamidobenzenesulfonyl azide; Et3N / acetonitrile / 2 h / 20 °C
7.1: 82 percent / Rh2(OAc)4*H2O / various solvent(s) / 0.5 h / 60 °C
8.1: 100 percent / H2O; dimethylsulfoxide / 1 h / 150 °C
9.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
9.2: tetrahydrofuran; hexane / -78 - 20 °C
10.1: 2.00 g / p-TsOH*H2O / toluene / 0.5 h / Heating
With
n-butyllithium; oxalyl dichloride; Rh2(μ-acetate)4(H2O); sulfuric acid; 4-acetamidobenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; toluene-4-sulfonic acid; acetic acid; triethylamine; N,N-dimethyl-formamide;
palladium dihydroxide;
In
tetrahydrofuran; 1,4-dioxane; hexane; water; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm034134+
