2,5,9,13-Tetraazatetradecanedioic acid, 13-[4-[[(2S)-4-amino-2-[[[2,4-bis(phenylmethoxy)phenyl]acetyl]amino]-1, 4-dioxobutyl]amino]butyl]-4-oxo-9-[(phenylmethoxy)carbonyl]-, bis(phenylmethyl) ester

Base Information

Chemical Name:2,5,9,13-Tetraazatetradecanedioic acid, 13-[4-[[(2S)-4-amino-2-[[[2,4-bis(phenylmethoxy)phenyl]acetyl]amino]-1, 4-dioxobutyl]amino]butyl]-4-oxo-9-[(phenylmethoxy)carbonyl]-, bis(phenylmethyl) ester
CAS No.:679812-67-0
Molecular Formula:C62H71N7O12
Molecular Weight:1106.29
Hs Code.:

2,5,9,13-Tetraazatetradecanedioic acid,
13-[4-[[(2S)-4-amino-2-[[[2,4-bis(phenylmethoxy)phenyl]acetyl]amino]-1,
4-dioxobutyl]amino]butyl]-4-oxo-9-[(phenylmethoxy)carbonyl]-,
bis(phenylmethyl) ester

Synonyms:

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Chemical Property of 2,5,9,13-Tetraazatetradecanedioic acid, 13-[4-[[(2S)-4-amino-2-[[[2,4-bis(phenylmethoxy)phenyl]acetyl]amino]-1, 4-dioxobutyl]amino]butyl]-4-oxo-9-[(phenylmethoxy)carbonyl]-, bis(phenylmethyl) ester

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Technology Process of 2,5,9,13-Tetraazatetradecanedioic acid, 13-[4-[[(2S)-4-amino-2-[[[2,4-bis(phenylmethoxy)phenyl]acetyl]amino]-1, 4-dioxobutyl]amino]butyl]-4-oxo-9-[(phenylmethoxy)carbonyl]-, bis(phenylmethyl) ester

There total 6 articles about 2,5,9,13-Tetraazatetradecanedioic acid, 13-[4-[[(2S)-4-amino-2-[[[2,4-bis(phenylmethoxy)phenyl]acetyl]amino]-1, 4-dioxobutyl]amino]butyl]-4-oxo-9-[(phenylmethoxy)carbonyl]-, bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

: 2899-60-7
Cbz-Gly-ONSuc

: 4,8-bis(benzyloxycarbonyl)-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine acetate

: 679812-67-0
4,8-bis(benzyloxycarbonyl)-N¹-(N^α-benzyloxycarbonylglycyl)-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1246/bcsj.77.331

Reference yield:

: 345898-28-4
4,8-bis(benzyloxycarbonyl)-N¹-(2,2,2-trichloroethoxycarbonyl)-N¹²-(tert-butoxycarbonyl)-4,8-diaza-1,12-dodecanediamine

: 679812-67-0
4,8-bis(benzyloxycarbonyl)-N¹-(N^α-benzyloxycarbonylglycyl)-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: CF₃CO₂H / CH₂Cl₂ / 0.5 h / 20 °C

2.1: 2.77 g / Et₃N / dimethylformamide / 1 h / 20 °C

3.1: CF₃CO₂H / CH₂Cl₂ / 1.5 h / 20 °C

4.1: 3.10 g / Et₃N / dimethylformamide / 22 h / 20 °C

5.1: Zn / 24 h / 20 °C

5.2: H₂S / 1.5 h / 20 °C

6.1: 69.4 percent / Et₃N / dimethylformamide / 18 h / 20 °C

With triethylamine; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.77.331

Reference yield:

: (4-amino-butyl)-(3-{benzyloxycarbonyl-[3-(2,2,2-trichloro-ethoxycarbonylamino)-propyl]-amino}-propyl)-carbamic acid benzyl ester

: 679812-67-0
4,8-bis(benzyloxycarbonyl)-N¹-(N^α-benzyloxycarbonylglycyl)-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2.77 g / Et₃N / dimethylformamide / 1 h / 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 1.5 h / 20 °C

3.1: 3.10 g / Et₃N / dimethylformamide / 22 h / 20 °C

4.1: Zn / 24 h / 20 °C

4.2: H₂S / 1.5 h / 20 °C

5.1: 69.4 percent / Et₃N / dimethylformamide / 18 h / 20 °C

With triethylamine; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.77.331