345898-28-4

Basic information

• Product Name: 2,6,10,15-Tetraazahexadecanedioic acid, 6,10-bis[(phenylmethoxy)carbonyl]-, 16-(1,1-dimethylethyl) 1-(2,2,2-trichloroethyl) ester
• CAS NO: 345898-28-4
• Molecular Formula: C34H47Cl3N4O8
• Molecular Weight: 746.128
• Mol File: 345898-28-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6,10,15-Tetraazahexadecanedioic acid, 6,10-bis[(phenylmethoxy)carbonyl]-, 16-(1,1-dimethylethyl) 1-(2,2,2-trichloroethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6,10,15-Tetraazahexadecanedioic acid, 6,10-bis[(phenylmethoxy)carbonyl]-, 16-(1,1-dimethylethyl) 1-(2,2,2-trichloroethyl) ester(345898-28-4)
• EPA Substance Registry System: 2,6,10,15-Tetraazahexadecanedioic acid, 6,10-bis[(phenylmethoxy)carbonyl]-, 16-(1,1-dimethylethyl) 1-(2,2,2-trichloroethyl) ester(345898-28-4)

Safety Data

• Hazardous Substances Data: 345898-28-4(Hazardous Substances Data)

Usage

General Description

2,6,10,15-Tetraazahexadecanedioic acid, 6,10-bis[(phenylmethoxy)carbonyl]-, 16-(1,1-dimethylethyl) 1-(2,2,2-trichloroethyl) ester is a chemical compound that is commonly used as a linker for bioconjugation and as a crosslinking reagent in the field of biochemistry and molecular biology. It is a derivative of 2,6-diaminohexanoic acid and has a molecular weight of 649.13 g/mol. 2,6,10,15-Tetraazahexadecanedioic acid, 6,10-bis[(phenylmethoxy)carbonyl]-, 16-(1,1-dimethylethyl) 1-(2,2,2-trichloroethyl) ester is known for its ability to form stable amide bonds and is often utilized in the synthesis of peptides and proteins. It is also used as a chemical modification agent for the functionalization of biomolecules and surfaces, making it a valuable tool in various scientific research applications.

Upstream product

• 380635-39-2 4-benzyloxycarbonyl-7-(2,2,2-trichloroethoxycarbonylamino)-4-azaheptanal diethyl acetal 
• 345898-27-3 4-benzyloxycarbonyl-7-(2,2,2-trichloroethoxycarbonylamino)-4-azaheptanal 
• 380635-36-9 3-(2,2,2-trichloroethoxycarbonylamino)propionaldehyde diethyl acetal 
• 345898-25-1 3-(2,2,2-trichloroethoxycarbonylamino)propionaldehyde 
• 129392-85-4 N-t-butoxycarbonyl-4-azidobutylamine 
• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 679812-62-5 4,8-bis(benzyloxycarbonyl)-N¹-[4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoyl]-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine 
• 679812-64-7 4,8-bis(benzyloxycarbonyl)-N¹-[3,N⁷-bis(benzyloxycarbonyl)-7-amino-3-azaheptanoyl]-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine 
• 679812-63-6 4,8-bis(benzyloxycarbonyl)-N¹-[4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoyl]-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine 
• 679812-66-9 4,8-bis(benzyloxycarbonyl)-N¹-[6-(benzyloxycarbonylamino)caproyl]-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine 
• 679812-67-0 4,8-bis(benzyloxycarbonyl)-N¹-(N^α-benzyloxycarbonylglycyl)-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine 
• 345898-30-8 4,8-bis(benzyloxycarbonyl)-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-N¹-(2,2,2-trichloroethoxycarbonyl)-4,8-diaza-1,12-dodecanediamine 
• 345898-29-5 4,8-bis(benzyloxycarbonyl)-N¹²-(N^α-tert-butoxycarbonylasparaginyl)-N¹-(2,2,2-trichloroethoxycarbonyl)-4,8-diaza-1,12-dodecanediamine 

Relevant articles and documents

Total synthesis of the novel spider toxin NPTX-594 from Nephila madagascariencis

A novel spider toxin, NPTX-594, comprised of four constituents: i.e., 2,4-dihydroxyphenylacetic acid (Dhpa), asparagine, 4,8-diaza-1,12-dodecanediamine (Dada), and lysine, was chemically synthesized. The synthetic compound was completely identical with the natural product as regards 1H NMR and mass spectra. The structure of NPTX-594 was thus determined synthetically to be N12-(Dhpa-Asn)-N1-Lys-Dada, as proposed by spectrometric elucidation.