Thiazole, 5-(4-methoxyphenyl)-2-phenyl-

Base Information

• Chemical Name: Thiazole, 5-(4-methoxyphenyl)-2-phenyl-
• CAS No.: 68004-04-6
• Molecular Formula: C16H13NOS
• Molecular Weight: 267.351
• Mol file: 68004-04-6.mol

Synonyms:

Chemical Property of Thiazole, 5-(4-methoxyphenyl)-2-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiazole, 5-(4-methoxyphenyl)-2-phenyl-

There total 20 articles about Thiazole, 5-(4-methoxyphenyl)-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-phenylthiazole (1826-11-5) + para-iodoanisole (696-62-8) → 5-(4-methoxyphenyl)-2-phenyl-1,3-thiazole (68004-04-6)

Guidance literature:

With triphenylphosphine; silver carbonate; [Pd((diphenylphosphanyl)ferrocene)Cl₂]*CH₂Cl₂; In water; at 60 ℃; for 24h;

DOI:10.1002/anie.200702141

Reference yield: 84.0%

methyl thiobenzoate (5873-86-9) + 4-(4-methoxyphenyl)-1-(methylsulfonyl)-1H-1,2,3-triazole (1200806-93-4) → 5-(4-methoxyphenyl)-2-phenyl-1,3-thiazole (68004-04-6)

Guidance literature:

methyl thiobenzoate; 4-(4-methoxyphenyl)-1-(methylsulfonyl)-1H-1,2,3-triazole; With C₁₉H₃₄O₈Rh₂; In chloroform; at 70 ℃; for 1h; Inert atmosphere; Glovebox; Molecular sieve; Sealed tube;

In chloroform; at 20 ℃; for 1h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.orglett.5b00960

Reference yield: 78.0%

5-iodo-2-phenylthiazole (1000029-07-1) + 4-methoxyphenylboronic acid (5720-07-0) → 5-(4-methoxyphenyl)-2-phenyl-1,3-thiazole (68004-04-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 16h;

DOI:10.1016/j.tet.2010.07.081

upstream raw materials:

N-[2-(4-methoxyphenyl)-2-ketoethyl]benzamide

2-phenylthiazole

1-bromo-4-methoxy-benzene

5-bromo-2-phenyl-1,3-thiazole

Refernces

• 1、 Miura, Tomoya,Funakoshi, Yuuta,Fujimoto, Yoshikazu,Nakahashi, Junki,Murakami, Masahiro. "Facile Synthesis of 2,5-Disubstituted Thiazoles from Terminal Alkynes, Sulfonyl Azides, and Thionoesters". supporting information. p. 2454 - 2457. Retrieved 2015/05/27.
• 2、 Tani, Satoshi,Uehara, Takahiro N.,Yamaguchi, Junichiro,Itami, Kenichiro. "Programmed synthesis of arylthiazoles through sequential C-H couplings". . p. 123 - 135. Retrieved 2014/01/06.