1,5-Benzoxazepin-4(5H)-one, 3-amino-5-(cyclopropylmethyl)-2,3-dihydro-2-phenyl-, (2R,3S)-

Base Information

Chemical Name:1,5-Benzoxazepin-4(5H)-one, 3-amino-5-(cyclopropylmethyl)-2,3-dihydro-2-phenyl-, (2R,3S)-
CAS No.:680231-67-8
Molecular Formula:C19H20N2O2
Molecular Weight:308.38
Hs Code.:

Synonyms:

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Chemical Property of 1,5-Benzoxazepin-4(5H)-one, 3-amino-5-(cyclopropylmethyl)-2,3-dihydro-2-phenyl-, (2R,3S)-

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Technology Process of 1,5-Benzoxazepin-4(5H)-one, 3-amino-5-(cyclopropylmethyl)-2,3-dihydro-2-phenyl-, (2R,3S)-

There total 5 articles about 1,5-Benzoxazepin-4(5H)-one, 3-amino-5-(cyclopropylmethyl)-2,3-dihydro-2-phenyl-, (2R,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 680231-66-7
tert-butyl [(2R,3S)-5-(cyclopropylmethyl)-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]carbamate

: 680231-67-8
(2R,3S)-3-amino-5-(cyclopropylmethyl)-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one

Guidance literature:: tert-butyl [(2R,3S)-5-(cyclopropylmethyl)-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 680231-47-4
(2R,3R)-3-hydroxy-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one

: 680231-67-8
(2R,3S)-3-amino-5-(cyclopropylmethyl)-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoromethane sulfonyl chloride; triethylamine / dichloromethane / 34 h / -40 - -25 °C

1.2: 2 h / -10 - 20 °C

2.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 2 h

3.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; trifluoromethane sulfonyl chloride; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 680231-48-5
(2R,3S)-3-azido-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one

: 680231-67-8
(2R,3S)-3-amino-5-(cyclopropylmethyl)-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 2 h

2: triethylamine / dichloromethane / 24 h / 0 - 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;