Technology Process of Cyclopentanone, 3,4-dimethyl-2-phenyl-2-(phenylmethyl)-, (2S,3R,4S)-
There total 4 articles about Cyclopentanone, 3,4-dimethyl-2-phenyl-2-(phenylmethyl)-, (2S,3R,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyllithium;
With
copper(l) iodide;
In
diethyl ether;
at 0 ℃;
for 0.166667h;
(4R,5S)-5-benzyl-4-methyl-5-phenyl-2-cyclopentenone;
In
diethyl ether;
at 0 ℃;
for 2h;
DOI:10.1016/j.tetasy.2004.01.008
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: vinyl acetate; PPL / 168 h / 20 °C
1.2: triphenylphosphine; formic acid; diethyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C
1.3: 80 percent / guanidine / methanol / 0.25 h / 0 °C
2.1: 60 percent / tetrahydrofuran; diethyl ether / 2 h / Heating
3.1: 90 percent / NaH / tetrahydrofuran / 5 h / 20 °C
4.1: CuI / diethyl ether / 0.17 h / 0 °C
4.2: 85 percent / diethyl ether / 2 h / 0 °C
With
copper(l) iodide; vinyl acetate; sodium hydride;
In
tetrahydrofuran; diethyl ether;
1.2: Mitsunobu reaction;
DOI:10.1016/j.tetasy.2004.01.008
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 60 percent / tetrahydrofuran; diethyl ether / 2 h / Heating
2.1: 90 percent / NaH / tetrahydrofuran / 5 h / 20 °C
3.1: CuI / diethyl ether / 0.17 h / 0 °C
3.2: 85 percent / diethyl ether / 2 h / 0 °C
With
copper(l) iodide; sodium hydride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tetasy.2004.01.008
