62486-26-4Relevant academic research and scientific papers
Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent- 2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents
Gurjar, Mukund K.,Wakharkar, Radhika D.,Singh, Anu T.,Jaggi, Manu,Borate, Hanumant B.,Shinde, Popat D.,Verma, Ritu,Rajendran, Praveen,Dutt, Sarjana,Singh, Gurvinder,Sanna, Vinod K.,Singh, Manoj K.,Srivastava, Sanjay K.,Mahajan, Vishal A.,Jadhav, Vinod H.,Dutta, Kakali,Krishnan, Karthik,Chaudhary, Anika,Agarwal, Shiv K.,Mukherjee, Rama,Burman, Anand C.
, p. 1744 - 1753 (2008/02/02)
A new series of 2,3-diaryl-4/5-hydroxy-cyclopent-2-en-1-one analogues replacing the cis double bond of combretastatin A-4 (CA-4) by 4/5-hydroxy cyclopentenone moieties was designed and synthesized. The analogues displayed potent cytotoxic activity (ICsub
2-Diazoacetoacetic acid, an efficient and convenient reagent for the synthesis of α-diazo-β-ketoesters
Meyer, Michael E.,Ferreira, Eric M.,Stoltz, Brian M.
, p. 1316 - 1318 (2008/02/03)
The formation of various α-diazo acetoacetic esters can be obtained in a single transformation with good to excellent yields using readily available 2-diazoacetoacetic acid. The Royal Society of Chemistry 2006.
Regioselective synthesis of trisubstituted cyclopentadienyl ligands from furans
Csák?, Aurelio G.,Contreras, Claudia,Mba, Myriam,Plumet, Joaquín
, p. 1451 - 1454 (2007/10/03)
1,2,3- And 1,2,4-trisubstituted cyclopentadienyl manganese tricarbonyl compounds have been synthesized regioselectively from furans following a common synthetic strategy. The key steps include the transformation of furylcarbinols into hydroxycyclopentenones followed by the conjugate addition of Grignard reagents under chelation directed conditions. This affords hydroxycyclopentanones which can be dehydrated to cyclopentenones. These compounds are further elaborated into the final targets by the 1,2-addition of organolithium reagents.
A new simple procedure for the isomerization of 2-furylcarbinols to cyclopentenones
D'Auria, Maurizio
, p. 185 - 194 (2007/10/03)
The previously reported acid catalyzed isomerization of 2-furylcarbinols to 5-alkyl-4-hydroxycyclopent-2-enones was performed in boiling water in the absence of any acid catalyst. In this case the reaction led to the formation of more stable isomer 2-alky
