62486-26-4Relevant articles and documents
Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent- 2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents
Gurjar, Mukund K.,Wakharkar, Radhika D.,Singh, Anu T.,Jaggi, Manu,Borate, Hanumant B.,Shinde, Popat D.,Verma, Ritu,Rajendran, Praveen,Dutt, Sarjana,Singh, Gurvinder,Sanna, Vinod K.,Singh, Manoj K.,Srivastava, Sanjay K.,Mahajan, Vishal A.,Jadhav, Vinod H.,Dutta, Kakali,Krishnan, Karthik,Chaudhary, Anika,Agarwal, Shiv K.,Mukherjee, Rama,Burman, Anand C.
, p. 1744 - 1753 (2008/02/02)
A new series of 2,3-diaryl-4/5-hydroxy-cyclopent-2-en-1-one analogues replacing the cis double bond of combretastatin A-4 (CA-4) by 4/5-hydroxy cyclopentenone moieties was designed and synthesized. The analogues displayed potent cytotoxic activity (ICsub
Regioselective synthesis of trisubstituted cyclopentadienyl ligands from furans
Csák?, Aurelio G.,Contreras, Claudia,Mba, Myriam,Plumet, Joaquín
, p. 1451 - 1454 (2007/10/03)
1,2,3- And 1,2,4-trisubstituted cyclopentadienyl manganese tricarbonyl compounds have been synthesized regioselectively from furans following a common synthetic strategy. The key steps include the transformation of furylcarbinols into hydroxycyclopentenones followed by the conjugate addition of Grignard reagents under chelation directed conditions. This affords hydroxycyclopentanones which can be dehydrated to cyclopentenones. These compounds are further elaborated into the final targets by the 1,2-addition of organolithium reagents.
