1-(4-(Hydroxyamino)phenyl)ethanone

Base Information

• Chemical Name: 1-(4-(Hydroxyamino)phenyl)ethanone
• CAS No.: 10517-47-2
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID20146994
• Nikkaji Number: J2.266.475A
• Wikidata: Q83011891
• Mol file: 10517-47-2.mol

Synonyms:4-Hydroxylaminoacetophenone;10517-47-2;1-(4-(Hydroxyamino)phenyl)ethanone;CCRIS 5067;1-[4-(hydroxyamino)phenyl]ethanone;4'-(Hydroxylamino)acetophenone;N-(p-Acetylphenyl)hydroxylamine;BRN 2206858;Ethanone, 1-(4-(hydroxyamino)phenyl)-;ACETOPHENONE, 4'-(HYDROXYAMINO)-;Ethanone, 1-[4-(hydroxyamino)phenyl]-;Ethanone, 1-[4-(hydroxyamino)phenyl]-;4-15-00-00037 (Beilstein Handbook Reference);4'-(Hydroxyamino)acetophenone;SCHEMBL11406233;DTXSID20146994

Chemical Property of 1-(4-(Hydroxyamino)phenyl)ethanone

Chemical Property:

• Vapor Pressure: 0.000204mmHg at 25°C
• Boiling Point: 314°Cat760mmHg
• Flash Point: 143.7°C
• PSA: 49.33000
• Density: 1.244g/cm³
• LogP: 1.76330
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

98%,99%, ^*data from raw suppliers

ETHANONE, 1-[4-(HYDROXYAMINO)PHENYL]- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)NO

Technology Process of 1-(4-(Hydroxyamino)phenyl)ethanone

There total 7 articles about 1-(4-(Hydroxyamino)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-nitrophenyl)ethanone (100-19-6) → N-(4-acetylphenyl)hydroxylamine (10517-47-2)

Guidance literature:

With 5% rhodium-on-charcoal; hydrazine hydrate; In tetrahydrofuran; at 0 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/anie.201409375

Reference yield: 16.0%

(4-nitrophenyl)ethanone (100-19-6) → N-(4-acetylphenyl)hydroxylamine (10517-47-2) + p-aminobenzophenone (99-92-3)

Guidance literature:

With ethanol; titanium(IV) oxide; for 0.0166667h; Irradiation;

DOI:10.1021/jo00055a033

Reference yield:

(4-nitrophenyl)ethanone (100-19-6) → N-(4-acetylphenyl)hydroxylamine (10517-47-2) + 1-[4-nitrophenyl]-1-ethanol (6531-13-1) + p-aminobenzophenone (99-92-3)

Guidance literature:

With baker's yeast; D-glucose; In phosphate buffer; ethanol; at 30 ℃; for 2h; pH=6.5;

DOI:10.1039/b408566c

upstream raw materials:

(4-nitrophenyl)ethanone

p-aminobenzophenone

1-(4-nitrosophenyl)ethan-1-one

Downstream raw materials:

p-aminobenzophenone

acetaldehyde

4,4'-diacetylazobenzene

N-(4-acetylphenyl)-N-hydroxyacetamide

Refernces

• 1、 Gu, Xianmo,Pei, Linjuan,Wang, Jie,Zhang, Jin,Zheng, Zhanfeng,Zhu, Pengqi. "Differences in the selective reduction mechanism of 4-nitroacetophenone catalysed by rutile- And anatase-supported ruthenium catalysts". . p. 1518 - 1528. Retrieved 2020.
• 2、 Cardinale, Luana,Jacobi Von Wangelin, Axel,Konev, Mikhail O.. "Catalyst-Free N-Deoxygenation by Photoexcitation of Hantzsch Ester". supporting information. . Retrieved 2020/02/15.